Hyperaldosteronism

This trial compares two blood pressure targets in people with primary aldosteronism, a hormonal condition that causes high blood pressure. One group aims for a systolic pressure below 120 mmHg (intensive), the other between 120 and 140 mmHg (standard). Over 6 to 10 years, researc…

This phase 2 trial tests a new drug called SAL0140 in 50 adults with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. Participants will receive either SAL0140 or a placebo for 12 weeks to see if it safely lowers b…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study tests an experimental drug called QLS1410 for people with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. The trial will compare the drug to a placebo in 60 adults to see if it safely lowers blood pres…

This study tests whether measuring certain hormones in a blood sample can accurately identify which patients with primary aldosteronism (a common cause of high blood pressure) have a curable adrenal tumor. Currently, diagnosis often requires an invasive procedure called adrenal v…

This study will look at 12 people having surgery to remove an adrenal gland (adrenalectomy) using robotic or laparoscopic methods. Some surgeries will use a green dye called Indocyanine Green (ICG) to help the surgeon see better, while others will not. The main goal is to track c…

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…