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Esophageal disorder
MONDO:0003749A non-neoplastic or neoplastic disorder that affects the esophagus. Representative examples of non-neoplastic disorders include esophagitis and esophageal ulcer. Representative examples of neoplastic disorders include carcinomas, lymphomas, and melanomas.
Also known as: disease of esophagus, disease of oesophagus, disease or disorder of esophagus, disease or disorder of oesophagus, disorder of esophagus, disorder of oesophagus, esophageal disorder, esophagus disease
1226 clinical trials for this condition and its sub-types, 20 tagged with Esophageal disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Esophageal disorder
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Neoplasm of esophagus 34 trials · 800 incl. sub-types
5 sub-types
- Esophageal cancer 408 trials · 791 incl. sub-types Sub-types →
- Benign neoplasm of esophagus 3 trials Sub-types →
- Esophageal neuroendocrine tumor 1 trial · 3 incl. sub-types Sub-types →
- Esophageal granular cell tumor 0 trials
- Neurofibroma of the esophagus 0 trials
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Gastroesophageal reflux disease 217 trials
1 sub-type
- Duodenogastric reflux 0 trials
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Esophagitis 22 trials · 102 incl. sub-types
6 sub-types
- Eosinophilic esophagitis 67 trials Sub-types →
- Peptic esophagitis 24 trials
- Crohn disease of the esophagus 1 trial
- Bacterial esophagitis 0 trials
- Fungal esophagitis 0 trials Sub-types →
- Viral esophagitis 0 trials
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Barrett esophagus 74 trials
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Esophageal varices 34 trials · 55 incl. sub-types
2 sub-types
- Esophageal varices with bleeding 29 trials
- Esophageal varices without bleeding 0 trials
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Achalasia 35 trials · 43 incl. sub-types
2 sub-types
- Idiopathic achalasia 12 trials
- Achalasia, familial esophageal 0 trials
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Esophageal ulcer 1 trial · 25 incl. sub-types
1 sub-type
- Peptic esophagitis 24 trials
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Dyskinesia of esophagus 20 trials
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Esophageal atresia 12 trials
1 sub-type
- Arroyo Garcia Cimadevilla syndrome 0 trials
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Isolated tracheo-esophageal fistula 2 trials
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Congenital esophageal stenosis 1 trial
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Esophageal diverticulosis 1 trial
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Esophageal leukoplakia 1 trial
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Laryngotracheoesophageal cleft 1 trial
6 sub-types
- Cleft larynx, posterior 0 trials
- Laryngotracheoesophageal cleft type 0 0 trials
- Laryngotracheoesophageal cleft type 1 0 trials
- Laryngotracheoesophageal cleft type 2 0 trials
- Laryngotracheoesophageal cleft type 3 0 trials
- Laryngotracheoesophageal cleft type 4 0 trials
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Congenital esophageal diverticulum 0 trials
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Esophageal duplication cyst 0 trials
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Esophageal tuberculosis 0 trials
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Megaesophagus 0 trials
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Tubular duplication of the esophagus 0 trials
Most studied deeper sub-types
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Could a new implant regrow your esophagus?
Disease control Recruiting nowThis study tests a new implant designed to help regrow a damaged section of the esophagus in up to 10 adults. The implant uses a special scaffold combined with the patient's own stem cells. The goal is to see if it is safe and can create a new, living esophageal tube. Participant…
Phase 1 • Sponsor: Harvard Apparatus Regenerative Technology, Inc. • Aim: Disease control
Last updated Sep 05, 2026 00:00 UTC
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New hope for toddlers with esophagus inflammation: dupilumab trial launches
Disease control Recruiting nowThis study tests the drug dupilumab in children as young as 6 months who have active eosinophilic esophagitis (EoE), a condition that causes inflammation in the esophagus and can make eating difficult. The goal is to see if the drug is safe and effective over 24 weeks. About 20 c…
Phase 3 • Sponsor: Regeneron Pharmaceuticals • Aim: Disease control
Last updated Aug 22, 2026 00:00 UTC
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Botox injection could replace surgery for Post-Esophagectomy stomach issues
Disease control Recruiting nowThis study tests whether a Botox injection into the stomach valve works as well as a surgical cut to prevent food from emptying too slowly after esophagus removal. About 170 adults having elective esophagectomy will be randomly assigned to one of the two procedures. Researchers w…
Phase 2/3 • Sponsor: The Cleveland Clinic • Aim: Disease control
Last updated Jun 27, 2026 09:08 UTC
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Swallow a tiny magnet: painless camera could replace endoscopy
Diagnosis Recruiting nowThis study tests a magnetically controlled capsule endoscope—a tiny camera you swallow—to painlessly screen the esophagus and stomach. Researchers will compare different swallowing protocols to see which gives the best view of the Z-line and other areas. 300 patients already sche…
Sponsor: Bács-Kiskun County Teaching Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 07:53 UTC
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New study aims to sharpen diagnosis of swallowing disorders
Knowledge-focused Recruiting nowThis study compares two techniques—esophageal manometry and EndoFLIP balloon measurements—to evaluate how well they assess swallowing difficulties (dysphagia). Researchers will enroll up to 1,000 patients with known esophageal conditions to see how these measurements relate to sy…
Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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New study investigates why some patients get worse reflux after esophagus surgery
Knowledge-focused Recruiting nowThis study looks at 200 adults to compare acid reflux-related damage in two groups: people who had a procedure called POEM for achalasia (a swallowing disorder) and people without any swallowing problems. Researchers will use endoscopy and acid monitoring to see if the pattern of…
Sponsor: Asian Institute of Gastroenterology, India • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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15,000 cancer Patients' data to unlock surgery secrets
Knowledge-focused Recruiting nowThis study is building a large database of 15,000 patients with esophageal or gastric cancers in France. Researchers will look back at medical records to see how patients fared after surgery, focusing on how long they stayed cancer-free. The goal is to learn more about survival, …
Sponsor: University Hospital, Lille • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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300,000 people get chest X-Rays in massive screening trial
Knowledge-focused Recruiting nowThis study is checking if chest X-rays can reliably find lung, heart, and esophagus problems in 300,000 adults during routine check-ups. People getting a health exam will have a chest X-ray, and if something looks off, they'll get a more detailed scan to confirm. The goal is to s…
Sponsor: Chinese Academy of Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:33 UTC
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Scientists dive deep into gut tissue to unravel childhood IBD
Knowledge-focused Recruiting nowThis study collects tissue, blood, and stool samples from 200 children with inflammatory bowel disease (IBD) or other gut disorders. Researchers will use a cutting-edge technique called spatial transcriptomics to map gene activity directly inside gut tissue. The goal is to better…
Sponsor: Seattle Children's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Could a simple blood test predict esophageal cancer?
Knowledge-focused Recruiting nowThis study is collecting medical history, blood, and tissue samples from 7,000 people with esophageal disorders like GERD or Barrett's esophagus. Researchers hope to find genetic or protein markers that signal a higher risk of developing esophageal cancer. The goal is to enable e…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Massive new registry aims to unlock secrets of swallowing disorders
Knowledge-focused Recruiting nowThis study is creating a large database of information from 10,000 people with esophagus problems like GERD, achalasia, and other motility disorders. Researchers will collect data from standard tests to better understand these conditions. The goal is to improve diagnosis and trea…
Sponsor: IRCCS San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:03 UTC
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Brush vs. forceps: which biopsy method spots esophageal problems better?
Knowledge-focused Recruiting nowThis study is creating a large database to compare two ways of taking tissue samples from the esophagus: standard forceps biopsies and a brush-based method called WATS3D. Researchers want to see if the brush method helps doctors find Barrett's esophagus or early warning signs of …
Sponsor: CDx Diagnostics • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:04 UTC