Endophthalmitis

This study tests whether a light-activated treatment called Rose Bengal photodynamic therapy can help people with a severe fungal eye infection called Fusarium keratitis. The infection can cause vision loss, and standard treatments may not always work. Participants receive either…

This study tests whether oral valganciclovir or ganciclovir eye drops can reduce the virus causing eye inflammation and prevent flare-ups. About 117 adults with CMV anterior uveitis will receive either antiviral treatment or placebo for 7 days, then some continue for 12 months. T…

This study will test whether adding a salt water (sodium chloride 5%) eye drop to standard antibiotic treatment helps heal bacterial eye infections faster. About 40 adults with bacterial keratitis will receive either antibiotics plus the salt drop or antibiotics alone. The goal i…

This study tests a new gel called IVIEW-1201 for treating fungal keratitis, a serious eye infection. About 60 people will receive either the gel or a control treatment. The goal is to see if the gel can clear the infection and heal the eye. While it aims to cure the infection, on…

This study tests whether a short course of the steroid prednisolone can prevent paradoxical immune reconstitution inflammatory syndrome (IRIS) in people with AIDS who have low CD4 counts and are starting HIV treatment. About 131 participants will receive either prednisolone or no…

This study will test whether a single antibiotic injection given during cataract surgery can prevent endophthalmitis, a rare but severe eye infection. About 60,000 people with cataracts will receive either the antibiotic or a placebo. The goal is to see if the antibiotic reduces …

This phase 2 trial tests whether adding a steroid eye drop (fluorometholone) to standard antibiotic treatment improves vision at 3 months in people with bacterial corneal ulcers. About 174 adults with mild to severe ulcers will be randomly assigned to get either the steroid plus …

This study aims to learn more about microbial keratitis, a serious eye infection, by examining 100 patients at Assiut University Hospital. Researchers will identify the germs causing the infection, look for risk factors, and track complications and outcomes. The goal is to improv…