Endocarditis

This study compares a long-acting antibiotic called dalbavancin to standard therapy for treating infective endocarditis, a serious infection of the heart valves caused by certain bacteria. Dalbavancin is given as one or two intravenous infusions, while standard therapy requires d…

This pilot study tests a long-acting antibiotic called oritavancin for treating gram-positive heart infections, such as infective endocarditis. The goal is to see if weekly IV doses can replace the usual weeks-long hospital stays and daily antibiotics. The study will enroll 20 ad…

This study tests a device called AngioVac that uses suction to remove infected growths (vegetations) from the right side of the heart in people with infective endocarditis. The trial will enroll 30 adults with large vegetations and track survival, infection clearance, and complic…

This study checks if a simple chest ultrasound (TTE) can accurately rule out infective endocarditis, a serious heart infection. If TTE is reliable, many patients can avoid a more invasive throat probe (TOE). Researchers will study 350 adults with suspected infection to compare th…

This study is a large international registry that will look back at the medical records of about 1,000 adults who were treated with the AngioVac system, a device that uses suction to remove blood clots, infected tissue, or other unwanted material from the heart and major blood ve…

This study looks at why a common gut bacterium, Enterococcus faecalis, sometimes travels to the heart and causes a serious infection called infective endocarditis. Researchers will analyze the gut bacteria of 90 adults with this bloodstream infection to see if an imbalance in the…