Encephalitis

This trial investigates whether a blood-filtering procedure called immunoadsorption (IA), combined with the drug rituximab, can improve neurological function in children aged 0-18 with severe anti-NMDAR encephalitis. Participants receive 10 IA sessions over 28 days plus weekly ri…

This phase 2 trial investigates whether lenalidomide, a drug that calms inflammation, can slow cognitive decline in people with mild cognitive impairment due to Alzheimer's disease. Participants take lenalidomide or a placebo for up to 12 months, followed by a 6-month washout per…

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This early-phase study tested whether infusing virus-fighting immune cells from a healthy donor could safely treat progressive multifocal leukoencephalopathy (PML), a serious brain infection in people with weak immune systems. Sixty adults with PML received up to three infusions …

This early-stage trial tested a new drug called ART5803 in 64 healthy adults to see if it is safe. ART5803 is a lab-made antibody designed to block harmful immune proteins that attack the brain in autoimmune encephalitis. The study gave single or multiple doses and compared them …

This study tested whether adding a powerful HIV drug called FUZEON® to standard antiretroviral therapy could help people with HIV who also have a rare brain infection called PML. PML is caused by a virus that attacks the brain when the immune system is weak. The goal was to see i…

This early-phase study tested a drug called NT-I7 in 12 adults with progressive multifocal leukoencephalopathy (PML), a serious brain infection that occurs in people with weakened immune systems. The goal was to see if NT-I7 could increase the number of infection-fighting white b…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This study tested a new rapid diagnostic panel called QIAstat-Dx that can detect 15 different bacteria, viruses, and fungi causing meningitis and encephalitis in just one hour. Researchers compared its accuracy against standard lab tests using 170 stored spinal fluid samples. If …

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This completed study looked at how people learn and remember associations, like names or where you met someone. Researchers compared healthy young and older adults with patients who have memory problems from Alzheimer's or semantic dementia. They used memory tests and brain scans…

This early-stage study tested a single dose of a new drug called ART5803 in 7 healthy adults to see if it is safe and how it interacts with another medicine (IVIG). The goal was to gather information for future research on autoimmune encephalitis, a condition where the immune sys…

This completed study tested blood samples from 878 people in Limousin, France, for antibodies against tick-borne encephalitis virus (TBEV). The goal was to see if the virus is present in the region, especially in patients with Lyme disease or neurological symptoms. Researchers al…

This completed study reviewed medical records of 50 obese adults with HSV encephalitis (a brain infection) to see how different ways of calculating acyclovir dose affect survival. Researchers looked at patients treated between 2013 and 2019 at six hospitals. The goal was to find …

This study looks at how a specific gene mutation (RANBP2) affects the immune system in people with Acute Necrotizing Encephalopathy type 1 (ANE1), a rare brain condition triggered by infections. Researchers compared blood samples from 35 participants, including patients with the …

This study looked at how gadolinium, a dye used in MRI scans, changes the QSM signal in the brain's white matter. 73 patients with inflammatory central nervous system conditions had MRI scans before and after receiving gadolinium. The goal was to measure any differences in the si…

This study looked at 22 people with PML, a rare brain infection caused by the JC virus in those with weakened immune systems. Researchers collected blood, urine, and spinal fluid samples over six months to measure immune checkpoint molecules and antiviral responses. The goal was …

This study looked at 20 adults who had NMDA receptor encephalitis, a rare brain condition that can cause psychosis, memory loss, and seizures. Researchers used questionnaires to measure thinking skills, mood, fatigue, and quality of life after the acute phase. The goal was to und…