Dysplasia of cervix

This Phase 3 trial tests a 9-valent HPV vaccine in over 9,000 healthy women aged 18-45. The vaccine targets nine HPV types linked to cervical cancer and genital warts. Researchers compare it to an existing 2-valent vaccine to see if it provides broader protection. The goal is to …

This study tests whether a program combining phone counseling and personalized text messages can help 360 cervical cancer survivors in Florida quit smoking better than standard quitline services. Participants must have a history of cervical cancer or high-grade cervical dysplasia…

This early-phase trial aimed to test whether curcumin (the active compound in turmeric) could safely help treat cervical precancer (CIN3). It planned to give 500 mg of curcumin twice daily for 12 weeks to women with CIN3. However, the study was withdrawn before enrolling any part…

This study tests whether a natural vaginal gel called CH2 can help women with mild cervical changes (CIN1) and high-risk HPV clear the infection and heal faster. Fifty women will use either the gel or a placebo twice a week for 24 weeks. Researchers will track Pap smear results a…

This study compares different HPV tests to find the best way to screen for cervical cancer in women living with HIV in Latin America. Over 1,000 participants will provide cervical, vaginal, and urine samples, plus undergo colposcopy and biopsies. The goal is to identify which tes…

This study compares two ways to check for returning cervical pre-cancer after treatment: the standard colposcopy exam versus a high-risk HPV DNA test. Over 2,200 women who were treated for high-grade cervical lesions will be randomly assigned to one of the two follow-up methods. …

This study tests a new, low-cost handheld 3D camera called CervImage for spotting early signs of cervical cancer. Researchers want to see if the device takes clear, useful images and is easy for doctors to use. The study includes 18 women, some with known HPV or cervical changes …

This study was designed to compare the standard Pap smear with a new blood test that looks for three proteins linked to cervical cell changes. It planned to include adults aged 18-85 in good health. However, the study was withdrawn before enrolling any participants, so no results…

This study looks at different methods to find early signs of cervical cancer in women living with HIV in the Dominican Republic. The goal is to see which screening approach works best to catch abnormal cells caused by HPV. About 619 women aged 25-49 will take part, helping doctor…

This study looks at which tests work best to find early signs of HPV-related cancer in the cervix or anus of people living with HIV. About 1,586 participants from Mexico and Puerto Rico will be tested using different methods, including HPV tests and cell samples. The goal is to c…

This study is testing whether women in Indonesia can successfully collect their own samples for HPV testing, which could make cervical cancer screening more accessible. Researchers will enroll 8,000 women aged 30-69 who haven't been screened recently. The goal is to see if self-c…

This study compares two ways to screen for cervical cancer: a Pap smear every 2.5 years versus an HPV test every 5 years. Over 76,000 women aged 25-69 in Australia are taking part, including those who received the HPV vaccine and those who did not. The goal is to see if the less …

This study tests whether applying an ice pack to the lower abdomen after vNOTES hysterectomy can lower pain and reduce the need for painkillers. 122 women having surgery for benign conditions will be randomly assigned to receive either standard care or standard care plus ice pack…

This study follows up to 1,000 adults who previously received gene therapy in a National Cancer Institute study. Researchers will contact participants yearly for up to 15 years to check for any long-term side effects, such as new cancers or nerve problems. No new treatments are g…

This observational study follows 168 women living with HIV in Zimbabwe who have been treated for cervical pre-cancer. Researchers want to learn how often the disease comes back and whether HPV or DNA tests can predict recurrence. Participants will be monitored every six months fo…