Could a simple HPV test every 5 years replace frequent pap smears?
NCT ID NCT02328872
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study compares two ways to screen for cervical cancer: a Pap smear every 2.5 years versus an HPV test every 5 years. Over 76,000 women aged 25-69 in Australia are taking part, including those who received the HPV vaccine and those who did not. The goal is to see if the less frequent HPV test is just as good at catching early signs of cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
HPV test (molecular test for human papillomavirus)
What this could lead to
If successful, this could show that HPV testing every 5 years is as good as or better than Pap smears every 2.5 years for preventing cervical cancer, potentially changing screening guidelines worldwide.
What could go wrong
This is a large, well-designed trial, but results depend on long-term follow-up and real-world compliance. The HPV test may detect more harmless infections, leading to unnecessary procedures.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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VCS Foundation
Carlton, Victoria, 3053, Australia