Dysentery

This study tests a new vaccine called Shigella4V, designed to protect against shigellosis, a severe diarrheal disease. Researchers are giving the vaccine to healthy adults, children, and 9-month-old infants to check its safety and whether it triggers a strong immune response. Dif…

This study tested a new vaccine designed to protect against severe diarrhea caused by Shigella bacteria. The vaccine was first given to adults in Europe, then to adults, children, and infants in Africa. Researchers checked for side effects and measured immune responses to find th…

This study tested a new vaccine called Shigella4V2 to protect infants against shigellosis, a severe diarrheal disease. Researchers gave the vaccine to 110 healthy 9-month-old babies to check its safety and how well it triggers an immune response. The goal is to find the best dose…

This early-stage study tested a new oral vaccine designed to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Fifty-three healthy adults received the vaccine to check for side effects and to see if it triggers an immune response. The goal is to develop …

This study tested a new Shigella vaccine in 200 healthy African infants to see if it can prevent severe diarrhea. The vaccine was given in two doses, and researchers measured immune responses and safety. The trial is now complete, and results will show whether this approach is pr…

This study tested a new vaccine called ShigETEC in healthy adults and children in Bangladesh. The vaccine aims to protect against two bacteria that cause severe diarrhea: Shigella and ETEC. Researchers gave three doses of the vaccine or a placebo to 196 participants to check if i…

This study tested whether a daily dose of Travelan (IMM-124E) tablets could prevent moderate-to-severe diarrhea in healthy adults deliberately infected with ETEC bacteria, a common cause of travelers' diarrhea. Sixty-three volunteers took either Travelan or a placebo for 7 days. …

This study tested whether analyzing a patient's DNA and RNA could help doctors pick the right drug for inflammatory diseases that don't fit standard categories. 32 adults with at least two affected organs (including skin) received one of six targeted therapies based on their mole…

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This study looked at whether giving hospital-level care to acutely ill adults in their own homes in rural areas works well. 160 people with various conditions like infections, heart failure, or COPD took part. The goal was to see if this approach could lower costs and help patien…

This study looked at how well a new, quick finger-prick test (LumiraDx CRP) measures CRP levels compared to a standard lab test. CRP is a marker of infection, inflammation, or tissue injury. 79 adults with symptoms of these conditions took part. The goal was to see if the new tes…

This early study tested a new radioactive tracer called 18F-FDS in 16 people with suspected bacterial or fungal infections. The tracer is designed to light up infection sites on PET/CT scans, helping doctors see exactly where an infection is. The goal was to check how the tracer …

This early study tested whether a special PET scan using a radioactive form of vitamin B9 (11C-PABA) can help doctors see infections deep inside the body. Researchers scanned 13 healthy people and patients with known or suspected infections. The goal was to see if this method can…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether a mix of two probiotics (Lactobacillus acidophilus and Limosilactobacillus reuteri) could shorten diarrhea in children aged 1 to 6 with acute infectious diarrhea. 145 children were randomly assigned to receive the probiotics or a placebo. Researchers mea…

This completed pilot trial tested two postbiotic supplements (ABB S3 and ABB C22) in 100 hospitalized patients with diarrhea or gut symptoms from tube feeding. The goal was to see if these nutritional supplements could ease symptoms like diarrhea, vomiting, and improve stool cons…

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study tested a mobile app called OASES that guides nurses and clinical officers in rural Uganda through emergency care steps for severe diarrhea, breathing problems, and seizures. About 15 clinicians used the app during simulated patient scenarios to see if it helped them fo…

This study looked at 156 critically ill patients to find out what factors help achieve the right levels of beta-lactam antibiotics in the blood. Researchers collected clinical data and used therapeutic drug monitoring to see which patients reached target concentrations. The goal …