Congenital diaphragmatic hernia
MONDO:0005711A posterolateral defect of the diaphragm that allows passage of abdominal viscera into the thorax, leading to respiratory insufficiency and persistent pulmonary hypertension with high mortality.
Also known as: diaphragmatic hernia, CDH, congenital diaphragmatic hernia, agenesis of hemidiaphragm, congenital diaphragmatic defect, unilateral agenesis of diaphragm
80 clinical trials for this condition and its sub-types.
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Broader categories
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Tiny balloon inside womb could help babies breathe
Disease control CompletedThis pilot study tested a procedure called FETO, where a tiny balloon is placed in the windpipe of an unborn baby with severe congenital diaphragmatic hernia (CDH). The goal was to see if the balloon could be safely placed and removed to help the lungs grow. Four pregnant women p…
Phase: NA • Sponsor: Dr Erin Perrone • Aim: Disease control
Last updated Jun 27, 2026 13:01 UTC
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Balloon in the womb: new device aims to save babies with underdeveloped lungs
Disease control CompletedThis study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Balloon in the womb may save babies with rare birth defect
Disease control CompletedThis study tested a procedure called FETO (fetal endotracheal occlusion) in 20 pregnant women whose babies had a severe form of congenital diaphragmatic hernia (CDH). In CDH, a hole in the diaphragm allows abdominal organs to move into the chest, preventing the lungs from growing…
Phase: NA • Sponsor: Michael A Belfort • Aim: Disease control
Last updated Jun 27, 2026 07:57 UTC
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Could a common heart drug save babies with a rare birth defect?
Disease control CompletedThis study looked at whether a medicine called milrinone can improve oxygen levels in newborns with congenital diaphragmatic hernia (CDH), a birth defect that causes severe breathing problems. The trial included 66 babies who were on breathing machines. The goal was to see if mil…
Phase: PHASE2 • Sponsor: NICHD Neonatal Research Network • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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New pain block may be safer for Kids' chest surgery
Symptom relief CompletedThis study tested two ways to manage pain in 70 children undergoing chest surgery. One method, the erector spinae plane block, was compared to the standard epidural block. The goal was to see which provides better pain relief and keeps the heart rate and blood pressure more stabl…
Phase: NA • Sponsor: Nguyen Dang Thu • Aim: Symptom relief
Last updated Jun 27, 2026 12:37 UTC
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Could a tiny dose of muscle relaxant make lung scopes safer?
Symptom relief CompletedThis study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…
Phase: NA • Sponsor: Harbin Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Physiotherapy students test muscle relief techniques on themselves
Symptom relief CompletedThis study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…
Phase: NA • Sponsor: Charles University, Czech Republic • Aim: Symptom relief
Last updated Jun 27, 2026 08:13 UTC
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Who should control your sedation during surgery? new study compares options
Symptom relief CompletedThis study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…
Phase: NA • Sponsor: GCS Ramsay Santé pour l'Enseignement et la Recherche • Aim: Symptom relief
Last updated Jun 27, 2026 07:59 UTC
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New turkish health survey could improve care for muscle and joint problems
Knowledge-focused CompletedThis study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…
Sponsor: Istanbul Bilgi University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Physios take on ER duty: study tests if they can replace doctors for back pain
Knowledge-focused CompletedThis study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…
Phase: NA • Sponsor: Bern University of Applied Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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Rare birth defect survivors: what is life really like?
Knowledge-focused CompletedThis study looked at the quality of daily life in children aged 5 to 18 who were born with a congenital diaphragmatic hernia (a hole in the diaphragm). Researchers asked the children, their parents, and siblings to fill out a questionnaire about physical and emotional well-being,…
Sponsor: Medical University of Vienna • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:09 UTC
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Fetal surgery immune mystery: why do some babies arrive too early?
Knowledge-focused CompletedThis study looked at 21 pregnant women and their babies to understand how surgery before birth changes the immune system. The goal was to find out if immune system activation might cause early labor. Researchers collected blood samples and studied the placenta to track immune cha…
Sponsor: Mayo Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:03 UTC
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Can CRPS patients imagine movement? new study investigates
Knowledge-focused CompletedThis completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nīmes • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Scientists hunt for hidden genes behind rare birth defect
Knowledge-focused CompletedThis study looked at the DNA of 73 children with a rare birth defect called isolated congenital diaphragmatic hernia (CDH), where a hole in the diaphragm allows organs to move into the chest. Researchers wanted to find new genetic changes that might cause the condition. They used…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:59 UTC
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Mind, spirit, and pain: new study explores what chronic pain patients really believe
Knowledge-focused CompletedThis study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …
Sponsor: Gulseren Demir Karakilic • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Tiny study tests smarter ventilator for babies born with diaphragm defect
Knowledge-focused CompletedThis pilot study looked at 8 newborns with congenital diaphragmatic hernia (a hole in the diaphragm) after surgery. Researchers compared two types of breathing machines: standard ventilation and a newer method called NAVA, which senses the baby's own breathing signals to provide …
Phase: NA • Sponsor: Hospices Civils de Lyon • Aim: Knowledge-focused
Last updated Jun 26, 2026 14:01 UTC