Congenital anomaly of the great arteries

This study tests whether injecting botulinum toxin (Botox) into fat pads around the heart's veins during cardiac surgery can prevent atrial fibrillation (AFib), a common and serious complication. About 220 adults undergoing heart surgery will receive either Botox or a placebo inj…

This study tests a special tube called a stent graft to repair damage in the upper part of the main artery from the heart (the ascending aorta). It is for people with bulges (aneurysms), tears (dissections), or other lesions that usually need open-heart surgery. The goal is to se…

This study planned to test a new surgical approach for people with pulmonary vein stenosis, a condition where the veins carrying blood from the lungs to the heart become narrowed. The procedure involved transplanting a donor's left atrium and pulmonary veins, followed by lifelong…

This study is testing a less invasive procedure using stent-grafts to treat various types of aortic disease, including aneurysms and dissections. It involves 170 participants who are considered too high-risk for traditional open surgery. The goal is to see if this endovascular ap…

This phase 3 trial tests whether upadacitinib (Rinvoq) can help people with Takayasu arteritis, a rare disease that inflames large arteries. About 56 adults who have had a recent relapse despite steroids will receive either upadacitinib or a placebo, along with a steroid taper. T…

This study compares two solutions, Custodiol and Custodiol-N, used to protect the heart during surgery for children with congenital heart defects. About 100 children will receive one of the two solutions while on a heart-lung machine. The goal is to see which one is safer and bet…

This study is testing a new heart valve, called the SAPIEN 3, in 150 people with congenital heart defects whose existing heart valves are not working properly. The valve is placed using a thin tube (catheter) through a blood vessel, avoiding open-heart surgery. The goal is to see…

This study tests whether combining standard monitoring tools with new light-based sensors can better detect a dangerous narrowing of the aorta in newborns. Infants under one month old with suspected aortic arch obstruction will be monitored using resonance Raman spectroscopy, pul…

This study collects tissue samples from 1,000 people having heart valve surgery to find genetic causes of calcific aortic valve disease. Researchers will compare normal and diseased tissue to understand why the disease develops. Participants must be at least 20 years old and have…

This study collects data from 1,200 patients undergoing surgery for aortic dissection, a life-threatening tear in the heart's main artery. Researchers will track death rates, strokes, and other complications to identify the safest surgical strategies. The goal is to improve outco…

This study follows 900 patients with a life-threatening tear in the aorta (type A aortic dissection) to compare outcomes between different surgical techniques. Researchers will track deaths, strokes, heart failure, and other complications within 30 days after surgery. The goal is…

This study follows 770 people who had aortic aneurysm repair using branched stent grafts. Researchers will check kidney function and other organ health over two years to see how different stent designs affect outcomes. The goal is to learn which approaches work best for preservin…

This study aims to uncover the genetic roots of aortic aneurysms and valve disease by analyzing tissue and blood samples from 3,000 participants. Researchers will look for new disease-causing genes and factors that affect disease severity. The goal is to build a biorepository to …

This study at Boston Children's Hospital is testing whether a thorough catheterization assessment can predict the outcome of pulmonary vein stenosis in children. Eighty children with known or suspected vein narrowing will undergo four tests during catheterization: angiography, ul…

This study follows 50 people who had a minimally invasive procedure to widen a narrowed heart valve (pulmonary balloon valvuloplasty). The goal is to see how often the right side of the heart struggles afterward and what factors might predict that. Researchers will track changes …