Calcium metabolic disease

This early-stage trial is testing an experimental drug called INZ-701 in adults with end-stage kidney disease who are on hemodialysis and have low levels of a natural substance called pyrophosphate, which helps prevent calcium buildup in blood vessels. The study aims to see if we…

This trial tests whether eating oat-based porridge daily, alongside standard prenatal calcium and vitamin D supplements, can improve calcium and vitamin D levels in pregnant women with mild to moderate hypocalcemia. Researchers will measure blood levels at weeks 8 and 33 of pregn…

This trial tests a new atherectomy device that uses a diamond-coated rotating crown to grind away calcium buildup in heart arteries. It aims to see if this device can safely and effectively prepare the artery for stent placement in people with calcified coronary artery disease. T…

This trial tests a new device that uses sound waves to break up calcium deposits in the heart's arteries, which can harden and narrow them. The study includes adults with coronary artery calcification who are eligible for a procedure to open blocked arteries. The goal is to see i…

This study looked at whether adding citrate to the fluid used during dialysis can slow the buildup of calcium in blood vessels. 54 adults on hemodialysis who already had some vessel hardening took part. Each person used a standard fluid for 12 months and a citrate fluid for anoth…

This completed study tested a two-step treatment for severely calcified leg artery disease in 50 patients. First, a shockwave device cracks the hard calcium deposits, then a drug-coated stent is placed to keep the artery open. The goal was to see if this approach is safe and effe…

This study tested two ways of delivering synthetic parathyroid hormone (PTH) to people with chronic hypoparathyroidism, a condition where the body doesn't make enough PTH, causing low calcium. Researchers compared using an insulin pump to give steady, small doses versus twice-dai…

This study tested whether dapagliflozin, a drug typically used for diabetes, can slow kidney decline, improve anemia, and support heart health in 100 adults with chronic kidney disease who do not have diabetes. Participants took either the drug or a placebo daily for 12 months al…

This study tested whether using contrast-enhanced mammography to guide breast biopsies is more accurate than the standard X-ray-guided method for suspicious calcifications. About 184 women with suspicious calcifications (BIRADS R3-R5) were randomly assigned to one of the two biop…

This study tested whether taking a probiotic called Lactobacillus acidophilus can help prevent bone loss and osteoporosis in women after menopause. 90 women aged 45-70 with a BMI between 27 and 35 took either the probiotic or a placebo. Researchers measured calcium levels and bon…

This study tested a device called PTeye that uses near-infrared light to help surgeons spot parathyroid glands during surgery for hyperparathyroidism. The goal was to see if it could reduce the number of tissue samples sent to the lab and lower the risk of needing a second surger…

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked back at 80 French patients with calciphylaxis, a rare and often fatal condition causing painful skin ulcers, mostly in people with severe kidney disease. Researchers aimed to describe patient characteristics, how doctors diagnose and treat the condition, and wha…

This study looked at whether vitamin K antagonists (a type of blood thinner) are linked to more calcium buildup in the aorta, the body's main artery. Researchers compared 73 patients—some on the drug for at least 6 months and some who never took it—using CT scans. The goal was to…

This study looked at how healthy adults' bodies handle calcium from drinking water. 41 participants drank low-calcium water first, then high-calcium water, and researchers measured changes in blood and urine calcium and parathyroid hormone levels after 2.5 hours. The goal was to …

This study looked at whether a simple score based on artery calcifications seen on a CT scan can help predict a serious complication called anastomotic leakage after right colon removal. Over 600 adults scheduled for surgery had their CT scans reviewed. The goal is to see if a hi…

This study tested whether an AI tool called Lunit INSIGHT CXR helps healthcare professionals read chest X-rays more accurately and quickly. Thirty doctors and radiographers reviewed 500 past chest X-rays from two UK hospitals, once with and once without AI help. The goal was to s…

This study looked at whether low vitamin D levels in the first trimester of pregnancy are linked to developing preeclampsia later on. Researchers measured vitamin D in over 3,000 pregnant women in France. The goal was to understand how common vitamin D deficiency is and if it rel…