Bronchiolitis obliterans syndrome
MONDO:0015265A lung disorder that is mainly associated with chronic allograft dysfunction after lung transplantation and that is characterized by inflammation and fibrosis of bronchiolar walls that reduce the diameter of the bronchioles and result in progressive and irreversible airflow obstruction.
Also known as: BOOP, constrictive bronchiolitis, organised pneumonia, organized pneumonia, bronchiolitis obliterans with obstructive pulmonary disease, BO, bronchiolitis exudativa, bronchiolitis obliterans
105 clinical trials for this condition and its sub-types.
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Broader categories
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Rollover study offers continued itacitinib access for chronic disease patients
Disease control TerminatedThis study provides continued access to itacitinib for 18 patients who were already benefiting from the drug in earlier trials. Participants have myelofibrosis, chronic graft-versus-host disease, or bronchiolitis obliterans after lung transplant. They continue their same dose as …
Phase: PHASE2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 28, 2026 00:00 UTC
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Inhaled drug aims to save transplanted lungs from silent threat
Disease control TerminatedThis study tested an inhaled form of cyclosporine A (L-CsA) added to standard care for lung transplant patients with bronchiolitis obliterans syndrome (BOS), a condition that scars the lungs' small airways. The goal was to see if the treatment could slow the decline in lung funct…
Phase: PHASE3 • Sponsor: Zambon SpA • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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New drug hope for lung damage after transplant falls short
Disease control TerminatedThis study tested the drug ruxolitinib to treat early lung damage in children and adults who had a stem cell transplant. Lung problems like bronchiolitis obliterans can be serious and hard to detect early. The trial aimed to see if adding ruxolitinib to standard care could improv…
Phase: PHASE2 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 12:04 UTC
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Experimental drug tested for rare lung condition after transplant
Disease control TerminatedThis early-stage study tested the safety of a drug called itacitinib in 8 adults who developed bronchiolitis obliterans syndrome (a type of lung scarring) after receiving a stem cell transplant from a donor. The goal was to see if the drug could help control the lung disease by b…
Phase: PHASE1 • Sponsor: M.D. Anderson Cancer Center • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Experimental drug itacitinib tested for lung transplant complication – study stopped early
Disease control TerminatedThis early-phase trial tested the drug itacitinib in 23 people who developed bronchiolitis obliterans syndrome (a type of chronic lung rejection) after a double lung transplant. The goal was to see if itacitinib could safely improve lung function. However, the study was terminate…
Phase: PHASE1, PHASE2 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:55 UTC
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Inhaler trial for Kids' lung decline after transplant ends early
Disease control TerminatedThis phase 3 trial tested whether a combination inhaler (fluticasone and salmeterol) could improve lung function in children aged 6–17 who had a drop in breathing capacity after a stem cell transplant. The study aimed to prevent bronchiolitis obliterans, a serious lung complicati…
Phase: PHASE3 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 26, 2026 17:44 UTC
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Breathing in a special gas reveals hidden lung damage in transplant patients
Knowledge-focused TerminatedThis study used a special MRI technique with a harmless gas called hyperpolarized xenon-129 to take detailed pictures of lung function in people who had a lung transplant. The goal was to see if this scan could detect early signs of chronic lung allograft dysfunction (CLAD), a co…
Sponsor: Xemed LLC • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Xenon gas MRI could spot lung transplant rejection early
Knowledge-focused TerminatedThis study tested a new type of MRI that uses inhaled xenon gas to create detailed images of the lungs. The goal was to see if it could detect early signs of chronic rejection in lung transplant recipients. Only 6 adults who had double lung transplants took part, and the study wa…
Phase: PHASE2 • Sponsor: The Hospital for Sick Children • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:27 UTC