Behcet disease

This study tests whether the Butantan-Dengue vaccine is safe and works well in people aged 12–59 with autoimmune rheumatic diseases (like rheumatoid arthritis or lupus) who are stable on low or no immune-suppressing drugs. Participants receive one vaccine dose and are monitored f…

This study tests whether the drug apremilast (Otezla) can reduce painful mouth ulcers in children aged 2 to 17 with Behçet's disease. About 60 participants will receive either apremilast or a placebo for 12 weeks to see if the drug works better than a dummy pill. The goal is to h…

This early-stage trial is testing a drug called RAY121 in 144 people with one of six immune diseases, including antiphospholipid syndrome and bullous pemphigoid. The drug works by blocking a specific part of the immune system (the complement pathway) that can cause tissue damage.…

This study investigates whether a 12-week treadmill walking program can improve metabolic syndrome in women with Behcet disease. Participants walk for 40 minutes three times a week. Researchers measure changes in cholesterol, triglycerides, blood sugar, blood pressure, and waist …

This study tests the drug lenalidomide in 42 adults with Behçet's syndrome who have stubborn mouth ulcers. Participants take 10 mg of lenalidomide daily for 12 weeks, then stop for 4 weeks of observation. The main goal is to see if the ulcers completely disappear by week 12.

This phase 2 trial is testing whether filgotinib, a drug already used for arthritis, can help people with three rare immune diseases: Behçet's disease, myositis, and IgG4-related disease. The goal is to see if it can control disease activity and reduce the need for long-term ster…

This study tests whether adding blood thinners (anticoagulants) to standard steroid treatment is better than steroids alone for deep vein clots in people with Behçet's syndrome. About 134 adults with a first or repeat clot will be randomly assigned to one of two groups. The goal …

This study looks at the long-term safety of the drug apremilast in children aged 2 and older with Behçet's disease (causing mouth ulcers) or aged 5 and older with juvenile psoriatic arthritis. About 48 kids who finished a previous study will take apremilast for up to 52 more week…

This study is observing 208 adults with Behçet's syndrome who have painful mouth and genital ulcers that did not improve with standard treatments. Researchers are tracking how well a biosimilar (a copy) of the drug ustekinumab controls these ulcers over 24 weeks, and comparing re…

This study is developing an artificial intelligence system that analyzes CT and MRI scans to diagnose and predict outcomes for digestive diseases like Crohn's disease, ulcerative colitis, and intestinal tuberculosis. Researchers are using data from 21 hospitals in China to train …

This study investigates whether a 12-week low-calorie diet can reduce tinnitus (ringing in the ears) in people who have both Behcet disease and obesity. Twenty participants will follow the diet, and researchers will measure changes in tinnitus severity, discomfort, and quality of…

This study tests whether a 12-week program of daily breathing exercises can improve lung function and reduce fatigue in adolescents with Behcet disease who have had lung surgery. Forty participants will do inspiratory muscle training at home, six days a week. Researchers will mea…

This study aims to learn how well heart scans (MRI, ultrasound, PET) can detect and predict outcomes in people with suspected or known inflammatory heart diseases. Researchers will follow 5,000 adults for one year to see how often heart involvement is confirmed and how it affects…

This study is building a large database and biobank from 2200 people with chronic inflammatory diseases like lupus, multiple sclerosis, severe asthma, and psoriasis. Researchers will collect blood samples and track disease activity over time using standard medical scores. The goa…

This study is building a large registry and biorepository of 5,000 adults with various rheumatic diseases like rheumatoid arthritis, lupus, and scleroderma. Researchers at Yale University will collect medical data and biological samples over time to better understand these condit…

This study looks at blood samples from children and adults with Behçet disease, as well as healthy children, to find biological markers that could improve diagnosis and monitoring. Researchers will analyze immune system signals, genetic material, and DNA changes. The goal is to b…

This study tracks the pregnancy experiences of women with vasculitis, a group of rare diseases causing blood vessel inflammation. Researchers will use online surveys to understand how vasculitis affects pregnancy and what outcomes occur. The goal is to gather information to help …

This study looks at how two rare diseases that cause blood vessel inflammation—Takayasu arteritis and Behçet's disease—affect physical strength, breathing, daily function, and emotional well-being. Researchers will compare 30 participants (patients and healthy volunteers) using s…