New drug targets immune overdrive in six rare diseases

NCT ID NCT06371417

Recruiting now Disease control Sponsor: Chugai Pharmaceutical Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 23, 2026 · Updated 2 times

Summary

This early-stage trial is testing a drug called RAY121 in 144 people with one of six immune diseases, including antiphospholipid syndrome and bullous pemphigoid. The drug works by blocking a specific part of the immune system (the complement pathway) that can cause tissue damage. The main goal is to check safety and how the body handles the drug, with a first look at whether it helps control the disease.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: RAY121 (a drug that blocks part of the immune system called the complement pathway)
What this could lead to: If successful, this could point toward a new treatment option for several rare immune diseases by calming overactive immune attacks.
What could go wrong: This is a very early Phase 1b trial, so it is primarily testing safety, not yet proving effectiveness. The drug may not work or could cause side effects, and results may not apply to all patients.

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Conditions

The condition(s) this trial relates to.

antiphospholipid syndrome Behcet disease bullous pemphigoid dermatomyositis immune-mediated necrotizing myopathy Purpura, Thrombocytopenic, Idiopathic thrombocytopenia due to immune destruction

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ANTIPHOSPHOLIPID SYNDROME (APS) BEHÇET'S SYNDROME (BS) BULLOUS PEMPHIGOID (BP) DERMATOMYOSITIS (DM) IMMUNE THROMBOCYTOPENIA (ITP) IMMUNE-MEDIATED NECROTIZING MYOPATHY (IMNM)

Contacts and locations

Locations

"SHATHD" EAD Sofia
NOT_YET_RECRUITING

Sofia, Sofia City Province, 1756, Bulgaria
AKH - Medizinische Universitaet Wien, Abteilung fuer Klinische Pharmakologie
WITHDRAWN

Vienna, 1090, Austria
AP-HP Hôpital Universitaire Pitié Salpêtrière
RECRUITING

Paris, Île-de-France Region, 75013, France
Amarillo Center for Clinical Research
WITHDRAWN

Amarillo, Texas, 79124, United States
Austin Neuromuscular Center
RECRUITING

Austin, Texas, 78759, United States
Box Hill Hospital
RECRUITING

Melbourne, Victoria, 3128, Australia
Campbelltown Public Hospital
RECRUITING

Sydney, New South Wales, 2560, Australia
Centre de Rhumatologie de l'Est du Quebec
RECRUITING

Rimouski, Quebec, G5L 8W1, Canada
Centro Clinico Academico Braga
NOT_YET_RECRUITING

Braga, Braga District, 471-243, Portugal
Centro Hospitalar de Vila Nova de Gaia/Espinho, E.P.E.
NOT_YET_RECRUITING

Vila Nova de Gaia, Porto District, 4434-502, Portugal
Centrul Medical Monza SRL
RECRUITING

Bucharest, Bucharest Municipality, 400015, Romania
Clinica Universidad de Navarra
RECRUITING

Pamplona, Community of Madrid & Navarre, 28027, Spain
Clinical Hospital Center "Sestre Milosrdnice"
RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
DIEX Recherche Sherbrooke Inc.
RECRUITING

Sherbrooke, Quebec, J1L 0H8, Canada
Diagnostic Consultation Center CONVEX EOOD
WITHDRAWN

Sofia, Sofia City Province, 1202, Bulgaria
Dr. Abdurrahman Yurtaslan Oncology Teaching and Research Hospital
WITHDRAWN

Ankara, Ankara, 06200, Turkey (Türkiye)
Hamamatsu University Hospital
RECRUITING

Hamamatsu, Shizuoka, 431-3192, Japan
Hokkaido University Hospital
RECRUITING

Sapporo, Hokkaido, 060-0808, Japan
Hopital Lapeyronie,Service d'Immuno Rhumatologie
RECRUITING

Montpellier, Occitanie, 34295, France
Hospital Universitari Vall d'Hebron, Internal Medicine Dept.
RECRUITING

Barcelona, Province of Barcelona and Catalonia, 08035, Spain
Hospital Universitari i Politecnic La Fe
WITHDRAWN

Valencia, Valencia, 46026, Spain
Hospital Universitario 12 de October
NOT_YET_RECRUITING

Madrid, Madrid, 28041, Spain
Hospital Universitario Ramon y Cajal, Servicio de Reumatologia
NOT_YET_RECRUITING

Madrid, Madrid, 28034, Spain
Hospital Universitario Reina Sofia
NOT_YET_RECRUITING

Córdoba, Province Of Córdoba, 14004, Spain
Hospital Universitario Virgen del Rocio
RECRUITING

Seville, Province Of Seville, 41013, Spain
Hospital for Special Surgery
WITHDRAWN

New York, New York, 10021, United States
Hyogo Prefectural Harima-Himeji General Medical Center
RECRUITING

Himeji, Hyōgo, 670-8560, Japan
IRCCS Istituto Scientifico Romagnolo Per Lo Studio Dei Tumori "Dino Amadori" - IRST
RECRUITING

Meldola, Forlì-Cesena Province, 47014, Italy
Immanuel Klinik Rudersdorf
RECRUITING

Rüdersdorf, Brandenburg, 15622, Germany
Institute Reumatologii I'm. Eleonory Reicher
RECRUITING

Warsaw, Masovian Voivodeship, 02-637, Poland
Institute of Science Tokyo Hospital
RECRUITING

Bunkyō-Ku, Tokyo, 113-8519, Japan
Istanbul University Istanbul Medical Faculty
WITHDRAWN

Istanbul, Istanbul, 34093, Turkey (Türkiye)
Istituto Clinico Humanitas
NOT_YET_RECRUITING

Milan, Milan Province, 20089, Italy
Johns Hopkins University
RECRUITING

Baltimore, Maryland, 21224, United States
Kindai University Hospital
RECRUITING

Sakai, Osaka, 590-0197, Japan
National Center of Neurology and Psychiatry
RECRUITING

Kodaira, Tokyo, 187-8551, Japan
National Taiwan University Hospital
RECRUITING

Taipei, 100229, Taiwan
Nerve and Muscle Center of Texas
RECRUITING

Houston, Texas, 77030, United States
Northwell Health, LLC PRIME
WITHDRAWN

Lake Success, New York, 11042, United States
Ohio State University
WITHDRAWN

Columbus, Ohio, 43203, United States
Okayama University Hospital
RECRUITING

Okayama, 700-8558, Japan
Oncology Institute Prof. Dr. Ion Chiricuta I.O.C.N.
RECRUITING

Cluj-Napoca, Cluj, 11658, Romania
Oregon Health & Science University
RECRUITING

Portland, Oregon, 97239, United States
Ospedale San Giovanni Bosco
WITHDRAWN

Torino, Turin Province, 10154, Italy
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
Sanatorium Profesora Arenbergera
WITHDRAWN

Prague, Prague, 11000, Czechia
Semmelweis Egyetem
RECRUITING

Budapest, 1083, Hungary
Sorlandet sykehus Kristiansand
RECRUITING

Kristiansand, Agder County, 4604, Norway
Specialty Hospital Medico
WITHDRAWN

Rijeka, Primorje-Gorski Kotar County, 51000, Croatia
Stavanger Universitetssjukehus
RECRUITING

Stavanger, Rogaland County, 4011, Norway
Sykehuset Ostfold Fredrikstad
NOT_YET_RECRUITING

Fredrikstad, Østfold fylke, 1603, Norway
Szegedi Tudomanyegyetem Szent-Gyorgyi Albert Klinikai Kozpont
NOT_YET_RECRUITING

Szeged, Csongrád-Csanád County, 6720, Hungary
Taichung Veterans General Hospital
RECRUITING

Taipei, 407219, Taiwan
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
The Royal Institution for the Advancement of Learning/McGill University
RECRUITING

Montreal, Quebec, H3A 0G4, Canada
The University of Osaka Hospital
RECRUITING

Suita, Osaka, 565-0871, Japan
Toho University Omori Medical Center
RECRUITING

Ōta-ku, Tokyo, 143-8540, Japan
Tohoku Medical and Pharmaceutical University Hospital
RECRUITING

Sendai, Miyagi, ９８３-８５１２, Japan
Tohoku University Hospital
RECRUITING

Sendai, Miyagi, 980-8574, Japan
Tokai University Hospital
RECRUITING

Isehara, Kanagawa, 259-1193, Japan
Toyama University Hospital
NOT_YET_RECRUITING

Toyama, 930-0194, Japan
UMC Utrecht
RECRUITING

Utrecht, Utrecht Province, 3584 CX, Netherlands
UMHAT "Prof. Dr. St. Kirkovich", AD
NOT_YET_RECRUITING

Stara Zagora, Stara Zagora Province, 6003, Bulgaria
UMHAT Sv Ivan Rilski EAD
RECRUITING

Sofia, Sofia City Province, 1612, Bulgaria
Universitaetsklinikum Carl Gustav Carus TU Dresden, Klinik und Poliklinik f. Dermatologie
NOT_YET_RECRUITING

Sachsen, Bundesländer, 1307, Germany
Universitaetsklinikum Erlangen
NOT_YET_RECRUITING

Erlangen, Bavaria, 91054, Germany
Universitaetsklinikum Schleswig Holstein - Campus Luebeck, Klinik f Dermatologie, Allergologie u Venerologie
WITHDRAWN

Lübeck, Schleswig-Holstein, 23538, Germany
Universitaetsklinikum Tuebingen
NOT_YET_RECRUITING

Tübingen, Baden-Wurttemberg, 72076, Germany
Universitaetsmedizin Goettingen
WITHDRAWN

Göttingen, Göttingen District, 3075, Germany
University Medical Centre Groningen UMCG
RECRUITING

Groningen, Groningen Province, 9713 GZ, Netherlands
University hospital centre Zagreb
NOT_YET_RECRUITING

Zagreb, City of Zagreb, 10000, Croatia
University of Alberta Hospital - Department of Anesthesiology and Pain Medicine
RECRUITING

Edmonton, Alberta, T6G 2B7, Canada
University of Alberta Hospital - Dermatology
RECRUITING

Edmonton, Alberta, T6G 2G3, Canada
University of California-Irvine
RECRUITING

Orange, California, 92868, United States
University of Pennsylvania, Perelman Center for Advanced Medicine
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Universtity of North Carolina at Chapel Hill
RECRUITING

Chapel Hill, North Carolina, 27599, United States
Westmead Hospital
RECRUITING

Sydney, New South Wales, 2145, Australia

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