Basal cell carcinoma

This Phase 3 study tests whether a gel containing patidegib can lower the number of new basal cell carcinomas (a type of skin cancer) on the face of adults with Gorlin syndrome. Participants apply the gel or a placebo to their face twice daily for a year. The study will compare h…

This study tests whether a gel containing a human growth factor (rhPDGF-BB) can help wounds heal faster after skin cancer removal on the head or neck. About 40 adults whose surgical wounds are too large to stitch closed will receive either the gel or a placebo. The goal is to see…

This study tested a new way to treat basal cell carcinoma, a common skin cancer. Instead of surgery, doctors used a jet-injection device to deliver a drug called ALA into the tumor, then activated it with red light. The trial included 16 adults with small, low-risk BCCs and aimed…

This Phase II trial tested the drug vismodegib in 104 people with advanced basal cell carcinoma, a type of skin cancer that had spread or could not be surgically removed. Participants took a daily capsule until their cancer worsened or side effects became too severe. The study me…

This study looked at the long-term safety of the cancer drug vismodegib in 19 patients with ovarian cancer, basal cell carcinoma, or metastatic colorectal cancer. All participants had previously taken vismodegib in an earlier Genentech trial and were expected to benefit from cont…

This study tested a microneedle patch that delivers the chemotherapy drug doxorubicin directly into nodular basal cell carcinoma, a common skin cancer. 90 adults with small, untreated tumors received either a low-dose, high-dose, or no-drug patch. The goal was to see if the patch…

This study tested a special skin graft called X A-DERM™ mADM in 16 people who had Mohs surgery to remove skin cancers like basal cell carcinoma or squamous cell carcinoma. The graft has a micro-textured surface designed to help the wound heal faster and leave a better scar. Resea…

This study tested the drug vismodegib given before surgery to people with advanced basal cell carcinoma (a type of skin cancer). The goal was to see if the drug could shrink the tumor enough to allow for a smaller, less invasive surgery. 55 participants took the drug for a period…

This early pilot study tested a new radioactive bandage called CivaDerm on 10 people with common skin cancers (basal cell or squamous cell carcinoma). The bandage delivers radiation directly to the skin surface, aiming to destroy cancer cells while sparing healthy tissue. The stu…

This early study tested a drug called cemiplimab, which helps the immune system attack cancer cells. The drug was injected directly into skin tumors (squamous cell or basal cell carcinoma) for 3 to 12 weeks before planned surgery. The main goal was to check safety and find the ri…

This study tested a new device that delivers targeted radiation to early-stage basal and squamous cell skin cancers. Thirty-six people aged 60 and older received treatment, and researchers tracked how well the cancer was controlled, cosmetic results, and quality of life. The goal…

This study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…

This study tested whether taking a daily pill called sonidegib for 12 weeks could shrink basal cell carcinomas in cosmetically sensitive areas like the face. The goal was to make surgery less invasive, reduce scarring, or even avoid surgery altogether by using only a topical crea…

This study tested whether a second round of treatment with tiny radioactive seeds (DaRT) could safely shrink or control skin, mouth, or soft tissue cancers that came back after the first treatment. Only 2 people took part, and researchers measured tumor response and side effects.…

This study tracked 287 people with advanced skin cancer (squamous cell or basal cell) to see how well the drug cemiplimab works outside of a clinical trial. Researchers measured tumor shrinkage, survival, and side effects. The goal was to understand real-world effectiveness and s…

This study tested a drug called sonidegib in 160 Chinese adults with a type of advanced skin cancer (basal cell carcinoma) that could not be treated with surgery or radiation. The drug is taken as a capsule and works by blocking signals that help cancer grow. The main goal was to…

This study tests a special microscope that lets doctors check if all cancer cells have been removed during surgery for common skin cancers. About 42 adults with head, neck, or skin cancer will take part. The goal is to see if this quick method is as accurate as the standard lab t…

This study tested a non-invasive imaging device called dermal optical coherence tomography (D-OCT) to diagnose basal cell carcinoma (a common skin cancer) around the eye area. Researchers compared its accuracy to standard biopsy results in 210 adults with suspected lesions. The g…

This study tested whether a special microscope (two photon microscopy) can detect leftover basal cell carcinoma during Mohs surgery as accurately as the usual lab method. 135 people having Mohs surgery for skin cancer took part. The goal was to see if the new imaging tool could g…

This study tested whether an artificial intelligence (AI) tool could help primary care doctors diagnose skin conditions more accurately. Nine doctors reviewed 30 images of various skin problems, first giving their own diagnosis and then a final diagnosis after seeing the AI's sug…

This study tested whether a daily application of diclofenac gel, a common anti-inflammatory drug, can reverse certain biomarkers in the skin that are linked to non-melanoma skin cancer. Twenty-four adults at risk for skin cancer applied the gel for 30 days, and researchers took s…

This study looked at whether giving people personalized information about their genetic risk for melanoma could encourage them to protect themselves from the sun. Over 2,000 adults received either standard sun safety tips or tailored advice based on their DNA. Researchers then tr…

Researchers are examining skin cancer among people whose jobs involve long hours in the sun. The study uses national administrative and medical records to describe who develops these cancers, including age, sex, region, cancer type, and disability outcomes. The goal is to underst…

This trial tests whether a 15-minute educational video and a list of suggested questions can improve understanding of immunotherapy among patients with advanced cancer and their caregivers. Participants are randomly assigned to receive the educational materials or usual care, and…

This study enrolled 500 skin cancer patients in China and analyzed over 1.2 million of their social media posts using artificial intelligence. The goal was to see if AI could detect signs of psychological distress and suicidal thoughts. Researchers hope this approach could lead t…

This study examined 119 people with precancerous or early skin cancer lesions to understand how cells change as they become cancerous. Researchers took small skin samples and analyzed their metabolism and protein markers. The goal was to learn more about the transition from harml…

This study tested a simple photo-based method to measure changes in nose shape and size after skin cancer surgery. Researchers took before-and-after photos of 68 patients who had surgery for common skin cancers. The goal was to see if this photographic approach could be a reliabl…

This study looked at 27 people with advanced basal cell skin cancer who were taking the drug vismodegib. The goal was to see if the amount of drug in their blood was linked to side effects like muscle cramps, hair loss, and taste changes. Researchers monitored patients for 6 mont…

This completed study looked at the long-term safety of the drug sonidegib in 323 adults with a type of skin cancer called locally advanced basal cell carcinoma. Participants took a daily 200 mg pill, and researchers tracked side effects, serious events, and deaths. The goal was t…

This study tested whether temporarily blocking and then releasing blood flow to a skin cancer (basal cell carcinoma) could increase blood flow to the tumor. Twelve adults with this type of skin cancer had their tumor's blood supply briefly clamped during surgery, and blood flow w…

This study tested whether combining two noninvasive techniques—a special skin scan (OCT) and sticky tape that collects skin cells—can accurately detect basal cell carcinoma, a common skin cancer. Fifty adults with suspected BCC were scanned and had tape strips taken from the same…