Bacterial arthritis

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This study compares two common antibiotic combinations—vancomycin with piperacillin/tazobactam versus vancomycin with meropenem—to see which is less harmful to the kidneys. About 852 hospitalized adults with serious infections will be randomly assigned to one of the two combos. T…

This study tests whether a treatment using special viruses (called phages) can safely and effectively treat infections in hip or knee replacements caused by Staphylococcus aureus bacteria. About 100 adults will receive either the phage therapy or a placebo during a standard surge…

This study tests whether antibiotic-coated braided sutures work as well as standard monofilament sutures in patients with infected hip or knee replacements. Surgeons currently use weaker monofilament sutures in infected cases to reduce bacterial growth. If the coated braided sutu…

This study tests whether specially designed viruses (bacteriophages) can eliminate a persistent bacterial infection in a hip replacement joint. One adult who has failed all standard surgeries and antibiotics will receive the viruses directly into the joint and through an IV for t…

This study tests whether adding a steroid (prednisone) to standard antibiotics can improve joint function in adults with septic arthritis, a serious joint infection. Two hundred participants will receive either prednisone or a placebo for 7 days. The main goal is to see if steroi…

This study looks at the long-term results of a surgery that replaces the missing growth plate at the top of the thigh bone in children who lost it due to a severe hip infection. Researchers will check how well the bone heals and how well the hip works at least five years after th…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study tests whether using ultrasound therapy before a steroid injection into the joint can improve pain and swelling for people with arthritis. About 100 adults with arthritis in their arms or legs will receive the combined treatment. The goal is to see if the ultrasound hel…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This observational study will look at 10,000 adults in intensive care units (ICUs) around the world during a single 24-hour period. Researchers want to find out how common infections and antibiotic-resistant bacteria are, how they are treated, and how patients recover. No new tre…

This research project aims to understand why older adults get more infections and why those infections can be more serious. By following 23,000 people aged 60 and older, scientists will collect health data and samples like blood and stool to study how the immune system changes wi…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This early-stage study will give a single dose of the experimental antibiotic gepotidacin to 20 hospitalized children aged 2 to 12 who are already receiving standard antibiotics for a bacterial infection or as a preventive measure. Researchers will measure how the drug moves thro…

This study will follow 200 people who have had a complex or revision hip replacement at University Hospitals Leuven. The goal is to track how many need another surgery and why, and to improve care by learning from real-world results. No new treatment is being tested—this is an ob…

This study looks at how the antibiotic delafloxacin spreads through the body in 20 adults with serious skin, soft tissue, bone, or joint infections. Researchers will measure drug levels in blood and in tissues collected during surgery. The goal is to understand if the drug reache…

This study will interview 63 people, including patients with prosthetic joint infections, their family members, and healthcare professionals, to understand their experiences. The goal is to use this information to create a therapeutic education program that helps patients manage …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will check if certain blood markers (like NLR and PLR) can predict how well people recover after surgery for a joint infection. Researchers will follow 200 adults who need a two-stage joint replacement revision. The goal is to find cheap, easy tests that help doctors p…

This study will follow 300 adults with severe infections in the ICU to see how levels of specialized pro-resolving mediators (SPMs)—natural molecules that help stop inflammation—change over time. Researchers will use blood samples already collected during routine care, so no extr…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…