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Autonomic nervous system disorder
MONDO:0001292A disease involving the autonomic nervous system.
Also known as: autonomic nervous disease, autonomic nervous system disease, autonomic nervous system disease or disorder, disease of autonomic nervous system, disease or disorder of autonomic nervous system, disorder of autonomic nervous system, disorder of peripheral autonomic nervous system, disorder of the autonomic nervous system
209 clinical trials for this condition and its sub-types, 59 tagged with Autonomic nervous system disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Autonomic nervous system disorder
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Dysautonomia 16 trials · 64 incl. sub-types
1 sub-type
- Primary dysautonomia 52 trials Sub-types →
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Autonomic nervous system neoplasm 0 trials · 60 incl. sub-types
3 sub-types
- Paraganglioma 53 trials · 57 incl. sub-types Sub-types →
- Ganglioneuroma 5 trials Sub-types →
- Sympathetic neurilemmoma 0 trials
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Sympathetic nervous system disorder 8 trials · 28 incl. sub-types
2 sub-types
- Sympathetic paraganglioma 0 trials · 16 incl. sub-types Sub-types →
- Ganglioneuroma 5 trials Sub-types →
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Pure autonomic failure 18 trials
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Autonomic dysreflexia 11 trials
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Autonomic neuropathy 7 trials · 10 incl. sub-types
2 sub-types
- Diabetic autonomic neuropathy 7 trials
- Horner syndrome 0 trials Sub-types →
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Baroreflex failure 1 trial
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Frey syndrome 0 trials
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Chronic hiccup 0 trials
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Harlequin syndrome 0 trials
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1 sub-type
- Parasympathetic paraganglioma 0 trials Sub-types →
Most studied deeper sub-types
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Fingertip wrinkle test may spot nerve damage
Diagnosis CompletedThis study looked at whether a 15-minute hand soak in warm water can help diagnose small fiber neuropathy, a condition that causes pain, numbness, and problems with automatic body functions. Researchers tested 38 adults and compared the wrinkling pattern of their fingertips to st…
Sponsor: HOSPITAL BRITANICO DE BUENOS AIRES • Aim: Diagnosis
Last updated Jun 27, 2026 08:02 UTC
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Heart-Guided exercise may keep aging bodies stronger
Prevention CompletedThis trial tests whether a smart circuit exercise program, which uses real-time heart rate monitoring to adjust intensity, can improve health in adults aged 65 to 85. Participants do moderate exercise three times a week for about eight weeks. Researchers measure changes in heart …
Sponsor: Chang Gung Memorial Hospital • Aim: Prevention
Last updated Aug 29, 2026 00:00 UTC
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Walking program shows promise for liver patients
Symptom relief CompletedThis study looked at whether a 16-week brisk walking program, combined with dietary advice, could improve heart rate control and blood vessel health in adults with early-stage cirrhosis (liver scarring). Fifty participants aged 45-75 who were not very active took part. The goal w…
Sponsor: King Chulalongkorn Memorial Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Could a blood pressure drug improve daily life for rare disease survivors?
Symptom relief CompletedThis study tested whether the drug Northera (droxidopa) is safe and helpful for adults with Menkes disease or Occipital Horn Syndrome who have trouble with low blood pressure and other symptoms of dysautonomia. Three participants took either the drug or a placebo in a crossover d…
Phase 1/2 • Sponsor: Stephen G. Kaler, MD • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Splash therapy: tiny study tests pool workouts for POTS
Symptom relief CompletedThis pilot study tested whether a 12-week aquatic occupational therapy program could reduce symptoms and improve quality of life in people with Postural Orthostatic Tachycardia Syndrome (POTS). Five adults with POTS completed three 60-minute pool sessions per week, including gent…
Sponsor: California State University, Dominguez Hills • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Ear-Zapping device shows promise for lupus fatigue
Symptom relief CompletedThis study tested a non-invasive device that stimulates the vagus nerve through the ear to see if it can reduce fatigue in people with lupus. 75 participants received either active or sham stimulation over two phases. The main goal was to measure changes in fatigue using a standa…
Sponsor: Rigshospitalet, Denmark • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Feldenkrais method shows promise for stress relief in sedentary women
Symptom relief CompletedThis pilot study explored whether the Feldenkrais Method, a gentle movement and awareness practice, could reduce stress and improve well-being in 24 healthy, sedentary women aged 26-59. Participants attended eight daily 90-minute sessions or served as controls. Researchers measur…
Sponsor: University of Palermo • Aim: Symptom relief
Last updated Jun 26, 2026 18:15 UTC
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Can online care help kids with nervous system disorder?
Knowledge-focused CompletedThis pilot study looks at whether it is possible to use online surveys and remote complementary healthcare sessions for children with dysautonomia, a condition that affects the automatic nervous system. Twenty children aged 5-14 will receive NERVE therapy and complete online asse…
Sponsor: Life University • Aim: Knowledge-focused
Last updated Aug 21, 2026 00:00 UTC
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Tiny nodules in connective tissue may reveal hidden clues about organ health
Knowledge-focused CompletedThis study looks at Chapman reflex points—small, palpable nodules in connective tissue thought to be linked to internal organ function—in healthy young adults. Researchers examine how often these points occur and whether they are associated with symptoms people may experience. Th…
Sponsor: The Touro College and University System • Aim: Knowledge-focused
Last updated Jul 10, 2026 00:00 UTC
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Hot springs boost altitude training for young athletes?
Knowledge-focused CompletedThis study tested whether taking hot spring baths (38°C for 20 minutes, three times a week) helps healthy teen athletes adapt to training at 1600 meters altitude. 27 participants were split into three groups: hot spring baths, hot water baths, or standard recovery. Researchers me…
Sponsor: Macao Polytechnic University • Aim: Knowledge-focused
Last updated Jun 28, 2026 00:00 UTC
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Breathing and posture tweak your Body's autopilot, study finds
Knowledge-focused CompletedThis study looked at how two simple techniques—special breathing and changing body position—affect the nervous system in healthy young adults. 27 people aged 18-25 took part. The goal was to measure changes in heart rate, blood pressure, and nerve activity, not to treat any disea…
Sponsor: Beijing Sport University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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COVID-19 ventilator patients may have hidden brainstem issues
Knowledge-focused CompletedThis study looked at how often brainstem problems occur in COVID-19 patients who are on a ventilator and deeply sedated in the ICU. Researchers checked brainstem reflexes using a simple scoring system, both during sedation and a few days after sedation stopped. The goal was to un…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:11 UTC
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Can a vein viewer detect nerve damage? new study explores simple diagnostic tool
Knowledge-focused CompletedThis study tested whether the ACCUVEIN, a device that projects veins onto the skin, can detect changes in vein size caused by the nervous system. Researchers had 12 healthy adults lie on a tilt table and slowly move from lying flat to standing upright. They used the device to see…
Sponsor: University Hospital, Angers • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC
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Neck pain may disrupt your Body's 'Autopilot' system
Knowledge-focused CompletedThis study looked at whether people with long-term neck pain have differences in their autonomic nervous system (the part that controls things like heart rate) compared to healthy people. Researchers measured heart rate variability in 56 participants while lying down, sitting, st…
Sponsor: National Yang Ming Chiao Tung University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Ear zaps and deep breaths: a new way to supercharge your workout?
Knowledge-focused CompletedThis completed study looked at whether stimulating a nerve in the ear (vagus nerve) or doing controlled breathing exercises can improve physical performance and affect the nervous system. 64 healthy, moderately active men took part. The goal was to see how these two approaches co…
Sponsor: Bahçeşehir University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:03 UTC
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Scientists uncover how Yesterday's stress lingers in your body
Knowledge-focused CompletedThis study looked at how stress changes the way your nervous system controls your heart rate. Researchers gave 23 healthy adults a hormone called cosyntropin or a placebo to see if it caused delayed changes in heart rate control. The goal was to understand the link between stress…
Sponsor: Brigham and Women's Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Hunting for hidden clues: study seeks early warning signs of parkinson disease
Knowledge-focused CompletedThis study looked for early biological signs (biomarkers) of Parkinson disease in 89 people with certain risk factors, such as family history, loss of smell, blood pressure drops, or a sleep disorder. Participants underwent brain scans, spinal taps, and other tests over several y…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Jun 26, 2026 19:15 UTC
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Short, intense workout may boost heart and brain in spinal cord injury
Knowledge-focused CompletedThis study tested whether a single session of high-intensity interval training (three 20-second all-out efforts on an arm bike) could improve heart and brain function in 30 people with spinal cord injury compared to uninjured controls. The goal was to see if this type of exercise…
Sponsor: State University of New York at Buffalo • Aim: Knowledge-focused
Last updated Jun 26, 2026 12:55 UTC