Atypical depressive disorder
MONDO:0001485A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.
99 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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AI city halls: could Robot-Run domes cure addiction and homelessness?
Disease control Not yet recruitingThis study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…
Phase: NA • Sponsor: Veterans Recovery Network Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Can a few support sessions prevent psychiatric readmissions?
Disease control Not yet recruitingThis study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…
Phase: NA • Sponsor: Stéphane Morandi • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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Can peer support keep homeless veterans out of the ER?
Disease control Not yet recruitingThis study looks at whether a program called EMPOWER, led by trained peer supporters, can help homeless veterans with substance use or mental health issues stay engaged in care and avoid repeated hospital stays or emergency visits. About 278 veterans in permanent supportive housi…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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Can computer exercises sharpen thinking in mental illness?
Symptom relief Not yet recruitingThis study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…
Phase: NA • Sponsor: The Royal Ottawa Mental Health Centre • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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Quick workout may calm anxiety in mental health patients
Symptom relief Not yet recruitingThis study tests whether a single 'Braining' group exercise session can quickly reduce anxiety in people receiving psychiatric care. Thirty participants will rate their anxiety before and after the session. The goal is to see if exercise can be a fast-acting tool to ease symptoms…
Phase: NA • Sponsor: Region Stockholm • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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Can swapping skills help heal minds? new study aims to find out
Knowledge-focused Not yet recruitingThis study tests a new program called CapExchange, where people with stable mental health conditions exchange practical skills with others in their community. The goal is to see if this approach is practical and helpful for improving well-being and social connection. About 10 to …
Phase: NA • Sponsor: EPSM de la Guadeloupe • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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New tool to measure mental health recovery being tested in france
Knowledge-focused Not yet recruitingThis study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…
Sponsor: Etablissement Public de Santé Mentale de Metz-Jury • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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New job program aims to boost employment for veterans with mental health struggles
Knowledge-focused Not yet recruitingThis study tests whether adding a career counseling program called Purposeful Pathways to standard job training helps veterans with mental health and substance use disorders find and keep quality jobs. About 254 veterans from three VA sites will take part. The goal is to improve …
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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New study aims to tackle physical health in mental health wards
Knowledge-focused Not yet recruitingThis study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…
Phase: NA • Sponsor: Charles Darwin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Massive study to uncover hidden mental toll of cancer
Knowledge-focused Not yet recruitingThis study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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Can better communication in occupational therapy improve client care? new study aims to find out.
Knowledge-focused Not yet recruitingThis study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…
Sponsor: Chang Gung Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC
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Can brain scans and gut bacteria predict suicide risk in young people?
Knowledge-focused Not yet recruitingThis study aims to better understand why young people (ages 18-25) with mood disorders may be at risk for suicide. Researchers will collect clinical, brain imaging, genetic, and microbiome data from 180 participants to identify risk factors. They will also test whether a non-inva…
Phase: NA • Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC