Atypical depressive disorder
MONDO:0001485A mood disorder that is characterized by mood reactivity (paradoxical anhedonia) and positivity, significant weight gain or increased appetite ("comfort eating"), excessive sleep or somnolence (hypersomnia), a sensation of heaviness in limbs known as leaden paralysis, and significant social impairment as a consequence of hypersensitivity to perceived interpersonal rejection.
26 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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New study: virtual therapy may cut opioid use after knee or hip surgery
Symptom relief Recruiting nowThis study tests a telemedicine-delivered cognitive behavioral program (RxWell) to help adults with anxiety or depression use fewer opioids after knee or hip replacement. About 150 participants will be enrolled. The program aims to improve mood and reduce painkiller use by provid…
Phase: NA • Sponsor: University of Pittsburgh • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Magic mushroom compound tested for hard-to-treat mental health struggles
Symptom relief Recruiting nowThis early-stage study at Yale is testing whether a single 25 mg dose of psilocybin is safe and tolerable for people whose daily life is impaired by mood, anxiety, trauma, or addiction symptoms. Fifty participants will receive the drug openly (everyone knows they get it) and be f…
Phase: PHASE1 • Sponsor: Yale University • Aim: Symptom relief
Last updated Jun 27, 2026 11:01 UTC
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Massive NIMH study seeks 16,000 volunteers to unlock secrets of mood and anxiety
Knowledge-focused Recruiting nowThis study at the National Institute of Mental Health screens up to 16,000 people with mood or anxiety disorders, as well as healthy volunteers, to see if they can join other research studies. Participants undergo evaluations like psychiatric interviews, brain scans, and lab test…
Sponsor: National Institute of Mental Health (NIMH) • Aim: Knowledge-focused
Last updated Aug 13, 2026 00:00 UTC
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Brain study seeks to unravel loneliness in mental illness
Knowledge-focused Recruiting nowThis study looks at how feeling lonely and being socially isolated affect the brain and daily life in people with serious mental illnesses like psychosis or schizophrenia. Researchers will use surveys, daily diaries, and brain scans to understand these connections. The goal is to…
Phase: NA • Sponsor: Massachusetts General Hospital • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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New study seeks to predict suicide risk in mood disorder patients
Knowledge-focused Recruiting nowThis study looks at why people with mood disorders may be at risk for suicide. Researchers will collect blood, urine, and survey answers from 300 participants to find patterns and build a model that predicts suicide risk. The goal is to better understand the factors involved so d…
Sponsor: Tianjin Anding Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Hidden health crisis: new screening aims to catch physical illness in mental health patients
Knowledge-focused Recruiting nowPeople with serious mental illness often have undiagnosed physical conditions like heart disease, diabetes, and cancer. This study tests whether adding routine physical health checks to psychiatric care helps find and treat these hidden illnesses. About 2,800 adults in Denmark wi…
Phase: NA • Sponsor: Amager Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Brain zaps may supercharge emotion control therapy
Knowledge-focused Recruiting nowThis study tests whether combining a one-time session of brain stimulation (rTMS or electrical scalp stimulation) with emotion regulation training helps people with mood, anxiety, or related disorders better control their emotions. 240 participants will learn either cognitive res…
Phase: NA • Sponsor: Duke University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Your eyes may reveal your meds: new study investigates
Knowledge-focused Recruiting nowThis study tests whether a special eye-tracking device (Gaize) can identify changes in eye movement patterns caused by long-term use of psychiatric medications. Researchers will observe 50 adults with conditions like ADHD, depression, or anxiety who have been on medication for ov…
Sponsor: Gaize • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC