Arbovirus fever

This study tests a new vaccine to prevent chikungunya, a virus that causes fever and severe joint pain. About 6,144 people aged 12 and older will receive either the vaccine or a placebo. Researchers will check if the vaccine safely prevents infection and reduces long-term joint p…

This Phase 3 trial tests a new yellow fever vaccine (vYF) in about 2,440 healthy children aged 9 months to 5 years. Researchers will compare vYF to two licensed vaccines (Stamaril and YF-VAX) to see if it triggers a strong immune response and is safe. Some children will also rece…

This study tests a new vaccine called BBV87 to see if it can safely protect people from chikungunya, a virus spread by mosquitoes that causes fever and joint pain. About 1000 healthy volunteers aged 12 to 65 will receive the vaccine and be monitored for side effects and immune re…

This study tests a vaccine against chikungunya virus in about 720 children aged 1 to under 12. The vaccine uses virus-like particles to train the immune system. Researchers will check if it is safe and triggers a strong immune response compared to a placebo.

This study looks at how well the yellow fever vaccine works and how safe it is for pregnant women compared to non-pregnant women. Researchers will enroll 270 women who received their first yellow fever vaccine either during or outside pregnancy. The goal is to ensure the vaccine …

This study tests whether giving newborns plasma from people who recently recovered from chikungunya can prevent brain swelling or damage. The trial will include 60 newborns whose mothers were infected around the time of birth. Half will receive the plasma transfusion, and their o…

This study tests whether giving patients donor-derived immune cells (VSTs) on a regular schedule can prevent dangerous viral infections after a stem cell transplant. 180 participants will be randomly assigned to receive VSTs either on a fixed schedule or only when a virus is dete…

This study tests whether specially grown donor immune cells (viral-specific T-cells) can safely treat viral infections that often occur after a stem cell transplant. These infections can be serious and sometimes don't respond to standard antiviral drugs. The approach aims to boos…

This study looks at immune cells in the skin of 40 healthy adults who have never received a yellow fever vaccine. Researchers will take small skin samples and blood to measure baseline levels of memory T cells. The goal is to understand the skin's natural immune state before vacc…

This study aims to collect samples and medical information from people of all ages who have or have been exposed to viral infections, including COVID-19 and herpes. Researchers want to understand how viruses affect healthy individuals versus those with weakened immune systems. Pa…

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…