Arbovirus fever

This Phase 2 study tests a new yellow fever vaccine (vYF) against the current licensed vaccine (Stamaril) in 690 healthy adults aged 18-60 in Europe and Asia. Participants receive one shot, and researchers measure immune response and safety over 5 years. The goal is to see if the…

This study will track 1200 people in Brazil who received the VLA1553 chikungunya vaccine as part of a pilot program. Researchers will compare how many vaccinated and unvaccinated people get chikungunya to see if the vaccine works in everyday life. The goal is to understand the va…

This observational study will follow 5,000 people who received the VLA1553 chikungunya vaccine as part of a pilot vaccination program. Researchers will monitor for specific safety concerns like chikungunya-like reactions, heart problems, and arthritis over 60 days. The goal is to…

This study was designed to test a vaccine called VLA1553 to protect healthy children aged 1 to 11 years from chikungunya, a virus spread by mosquitoes. The plan was to give the vaccine or a comparison shot to over 3,000 children and check for immune responses and safety. However,…

This Phase 3 trial follows adults who previously received the VLA1553 chikungunya vaccine to see how long their antibodies last and to monitor long-term safety. About 363 participants are being tracked for up to several years. The goal is to determine if a single shot can provide…

This study looks at whether a special team of doctors and nurses can treat adults with suspected infections at home, instead of sending them to the hospital. About 500 people will be randomly assigned to either standard hospital care or home-based care from a mobile response team…

This phase 3 trial tests whether methotrexate, a drug used for rheumatoid arthritis, can reduce joint swelling and pain in people with chronic arthritis caused by chikungunya virus. About 150 adults in Colombia will receive either methotrexate or a placebo for 6 months. The goal …

This study evaluates a new blood test called Xpert Tropical Fever that can quickly detect several tropical diseases like malaria, dengue, and Zika from a small blood sample. Researchers will enroll 2,500 people with fever symptoms to see how accurate the test is compared to stand…

This study tests a gentle electrical stimulation of the vagus nerve in the ear (taVNS) to reduce chronic joint pain in the legs caused by Chikungunya fever. 51 adults with pain lasting at least 3 months will be randomly assigned to taVNS, standard TENS, or a sham device. The goal…

This study tests a new AI-powered toolkit designed to help public health officials at local CDC offices respond more quickly to emerging infectious diseases such as COVID-19, mpox, influenza, and dengue. The toolkit combines data analysis, risk assessment, decision support, and e…

This study looks at how the immune system of patients in the intensive care unit (ICU) responds to severe infections caused by viruses or bacteria. Researchers will take extra blood samples from 38 adults to analyze immature granulocytes, a type of immune cell. The goal is to see…

This study aimed to see if a computer could learn to predict how long a patient would stay in a home hospital program. Researchers planned to use data from past patients to train the computer. However, the study was withdrawn before any patients were enrolled, so no results are a…

This study will test over 5,300 people in about 10 Brazilian municipalities for antibodies to the chikungunya virus before a pilot vaccination campaign with the VLA1553 vaccine. The goal is to see how many people have already been exposed to the virus and how that might affect va…

This study looks at immune cells from people with autoimmune diseases (like lupus), people with infections, and healthy volunteers. Researchers want to understand how these cells differ and what makes them attack the body in autoimmune conditions. The study involves blood and bon…