Appendicitis

This study tests whether treating children with uncomplicated appendicitis using antibiotics alone works as well as surgery. About 724 children aged 5 to 15 will be randomly assigned to receive either antibiotics or an operation. The goal is to see if the antibiotic approach lead…

This trial compares a one-day course of antibiotics after appendix surgery to the standard five-day course in 200 children and adults with uncomplicated appendicitis. The goal is to see if the shorter course prevents infections just as well, while reducing side effects and costs.…

This early study tests a new robotic surgical system (Revolve) in 3 adults with simple appendicitis who are already scheduled for appendix removal. The robot helps the surgeon work more precisely during minimally invasive surgery. The main goal is to see if the device can safely …

This study will compare two methods of closing the skin after open appendix surgery: standard interrupted stitches versus a continuous stitch under the skin plus a small drain. The goal is to see which method leads to fewer wound infections and better healing. About 100 people ag…

This study tests a new, non-surgical treatment called ERAT for mild appendicitis. Instead of removing the appendix, doctors use a flexible tube through the colon to clear the blockage and infection. The trial will compare ERAT to standard laparoscopic surgery in 376 adults to see…

This study tests a simple 10-item checklist that parents can use during a video call to help doctors figure out if a child's belly pain is appendicitis. About 1,500 children aged 3 to 16 with stomach pain will try the checklist with a medical student, then get standard care. The …

This study compares two ways of adjusting the air cushion (cuff) on the breathing tube used during general anesthesia in children having laparoscopic appendectomy. One group uses the standard finger-palpation method, while the other uses a pressure sensor to keep the cuff within …

This study will see if using a Garmin smartwatch to continuously track heart rate, breathing rate, and oxygen levels can help doctors spot early warning signs in hospitalized children in Ghana. About 250 children with traumatic injuries or after appendix surgery will wear the wat…

This pilot study looks at whether it is safe to stop giving antibiotics after surgery for a burst (perforated) appendix. About 100 adults will be randomly assigned to receive either antibiotics or no antibiotics after their operation. The main goal is to see if a larger study is …

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study will look at 150 infants and children aged 1 month to 4 years who are admitted to a hospital gastroenterology unit with a gastrointestinal disease. The goal is to find out how common electrolyte disturbances (like low sodium or potassium) are in these children. By meas…