Aortic disorder
MONDO:0005561Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC)
Also known as: aorta disease, aorta disease or disorder, disease of aorta, disease or disorder of aorta, disorder of aorta
646 clinical trials for this condition and its sub-types, 45 tagged with Aortic disorder itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Aortic disorder
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Aortic valve disorder 77 trials · 398 incl. sub-types
5 sub-types
- Aortic valve stenosis 319 trials · 322 incl. sub-types Sub-types →
- Aortic valve insufficiency 56 trials Sub-types →
- Familial bicuspid aortic valve 6 trials · 21 incl. sub-types Sub-types →
- Aortic valve calcification 14 trials
- Aortic valve prolapse 0 trials
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Aortic aneurysm 104 trials · 209 incl. sub-types
2 sub-types
- Abdominal aortic aneurysm 114 trials Sub-types →
- Thoracic aortic aneurysm 76 trials
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Aorta coarctation 13 trials
2 sub-types
- Atypical coarctation of aorta 0 trials
- Autosomal dominant coarctation of aorta 0 trials
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Leriche syndrome 8 trials
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Renal artery disease 3 trials · 7 incl. sub-types
3 sub-types
- Renal artery atheroma 4 trials
- Renal artery obstruction 3 trials
- Nephrosclerosis 0 trials
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Aortic atherosclerosis 1 trial · 5 incl. sub-types
1 sub-type
- Renal artery atheroma 4 trials
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Superior mesenteric artery syndrome 2 trials
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Tricuspid valve stenosis 2 trials
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Aortitis 1 trial
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Aneurysm of sinus of Valsalva 0 trials
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Aorta atresia 0 trials
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Aortic malignant tumor 0 trials
1 sub-type
- Aorta angiosarcoma 0 trials
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Neoplasm of aortic body 0 trials
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Subaortic stenosis, membranous 0 trials
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Tricuspid valve prolapse 0 trials
Most studied deeper sub-types
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Registry tracks graft performance in 1,200 artery patients
Disease control Recruiting nowThis study follows 1,200 people who received special fabric tubes (grafts) to repair or replace damaged arteries in the neck, belly, or legs. Researchers want to see how well the grafts work over time and how often problems like blockages or infections happen. It is an observatio…
Sponsor: Intervascular • Aim: Disease control
Last updated Sep 13, 2026 00:00 UTC
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New device aims to make aortic surgery safer
Disease control Recruiting nowThis study tests a new device called Rapidlink, used during open surgery to repair or replace blood vessels in the chest. It involves 150 adults already scheduled for aortic surgery. The goal is to see if the device reduces major complications like stroke or death. Participants w…
Sponsor: Vascutek Ltd. • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New balloon aims to reduce heart rhythm problems during valve replacement
Disease control Recruiting nowThis study tests a new balloon device used during a minimally invasive heart valve replacement procedure (TAVI) for people with severe aortic stenosis. The main goal is to see if the balloon causes fewer heart rhythm problems, like blockages that might need a pacemaker. About 93 …
Sponsor: Biosensors Europe SA • Aim: Disease control
Last updated Jun 27, 2026 12:07 UTC
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Shockwave therapy opens hardened arteries for Life-Saving aortic repair
Disease control Recruiting nowThis study tests a special balloon that uses shockwaves to crack calcium buildup in the iliac arteries, making it possible to deliver large aortic stents. About 40 adults with severe aortic disease and hardened arteries will be enrolled. The goal is to see if this approach is saf…
Sponsor: EndoCore Lab s.r.l. • Aim: Disease control
Last updated Jun 27, 2026 12:00 UTC
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Surgeons tailor Stent-Grafts to fix aortic aneurysms in new trial
Disease control Recruiting nowThis study tests whether stent-grafts that surgeons customize for each patient's anatomy can safely treat aortic aneurysms. Thirty adults with aneurysms at risk of rupture will receive a physician-modified graft and be followed for five years. The goal is to see if this personali…
Sponsor: Chandler Long, MD • Aim: Disease control
Last updated Jun 27, 2026 09:01 UTC
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New brain filter aims to prevent strokes during heart procedure
Disease control Recruiting nowThis study tests a new device called the Encompass F2, which is designed to catch debris that might travel to the brain during a common heart valve replacement procedure (TAVR). The goal is to see if it reduces the risk of stroke and brain damage compared to standard care. About …
Sponsor: EnCompass Technologies, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Cooler or warmer? new trial tests best temperature for aortic surgery safety
Disease control Recruiting nowThis study tests whether cooling patients to 32°C (mild) or 26°C (moderate) during aortic arch surgery better protects the brain and kidneys. 282 adults having planned aortic hemiarch surgery will be randomly assigned to one temperature. The goal is to see which temperature reduc…
Sponsor: Ottawa Heart Institute Research Corporation • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Fish oil infusion may shield heart surgery patients from dangerous rhythm disorder
Prevention Recruiting nowThis study tests whether giving fish oil through a vein during heart surgery can prevent a common complication called atrial fibrillation (irregular heartbeat) and help patients recover faster. About 550 high-risk adults having elective heart surgery will receive either fish oil …
Phase 2 • Sponsor: GCP-Service International West GmbH • Aim: Prevention
Last updated Jul 10, 2026 00:00 UTC
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New drug aims to shield kidneys from heart surgery harm
Prevention Recruiting nowThis study tests a drug called BX-001N to see if it can prevent acute kidney injury in people having heart surgery. About 40 adults will receive either a low dose, high dose, or a placebo. The goal is to see if the drug can keep kidneys working well after surgery.
Phase 2 • Sponsor: Bilix Co.,Ltd. • Aim: Prevention
Last updated Jul 03, 2026 00:00 UTC
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Gentle touch after Open-Heart surgery: can massage help you breathe easier?
Symptom relief Recruiting nowThis study tests whether myofascial release, a gentle hands-on therapy, can help people recover after heart surgery that splits the breastbone. Fifty adults with heart disease will receive either standard physical therapy or standard therapy plus seven daily sessions of myofascia…
Sponsor: Siou-Pin Huang • Aim: Symptom relief
Last updated Jun 27, 2026 14:00 UTC
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Simple tube change could cut Post-Surgery heart flutter by 30%
Symptom relief Recruiting nowThis study tests whether keeping a special chest tube in place for up to 3 days after heart surgery can lower the chance of developing a fast, irregular heartbeat called atrial fibrillation. About 624 adults having routine heart surgery will be randomly assigned to get the tube p…
Sponsor: Region Skane • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Single shot vs. catheter: which pain block is better for belly surgery?
Symptom relief Recruiting nowThis study compares two methods of pain control for people having open abdominal surgery. One group gets a single injection of a long-lasting numbing medicine into the belly muscles during surgery. The other group gets a standard numbing medicine through small tubes placed in the…
Phase 4 • Sponsor: Hartford Hospital • Aim: Symptom relief
Last updated Jun 26, 2026 12:40 UTC
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New MRI techniques aim to sharpen heart disease detection
Knowledge-focused Recruiting nowThis study aims to develop and test new MRI methods for imaging the heart and blood vessels to improve diagnosis and management of heart disease. It will enroll up to 3,400 adults, including both patients with heart conditions and healthy volunteers. Participants will undergo MRI…
Sponsor: National Heart, Lung, and Blood Institute (NHLBI) • Aim: Knowledge-focused
Last updated Sep 17, 2026 00:00 UTC
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New bedside system could prevent strokes during heart surgery
Knowledge-focused Recruiting nowThis study involves 40 adults undergoing aortic arch surgery to repair aneurysms or dissections. Researchers are testing a new bedside system that measures brain chemicals in near real-time to detect early signs of oxygen deprivation. The goal is to prevent strokes and confusion …
Sponsor: Barts & The London NHS Trust • Aim: Knowledge-focused
Last updated Sep 10, 2026 00:00 UTC
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Can Real-World data improve vascular surgery outcomes?
Knowledge-focused Recruiting nowThis study is a large registry that collects safety and performance data on Terumo Aortic knitted and woven grafts and cardiovascular patches used in standard clinical practice. It will include about 2,000 patients who need these devices to repair or bypass damaged blood vessels,…
Sponsor: Vascutek Ltd. • Aim: Knowledge-focused
Last updated Aug 22, 2026 00:00 UTC
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Heart imaging revolution? 1000-Person study tests new MRI tech
Knowledge-focused Recruiting nowThis study will test new MRI methods to find early signs of heart disease in 1000 adults. Researchers want to see if these scans can detect tiny changes in heart muscle before standard tests do. Participants will have MRI scans and blood work, but no treatment is given. The goal …
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Aug 02, 2026 00:00 UTC
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Researchers test study materials for clarity before patient use
Knowledge-focused Recruiting nowThis study asks 30 staff and students at the University of Nottingham to review draft recruitment materials for a future study on thoracic aortic disease. Participants will give feedback on how clear, easy to read, and appropriate the documents are. The goal is to improve these m…
Sponsor: University of Nottingham • Aim: Knowledge-focused
Last updated Jul 02, 2026 00:00 UTC
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Massive heart surgery database aims to save lives through data
Knowledge-focused Recruiting nowThis study is creating a large database of information from 10,000 adults undergoing heart surgery. Researchers will collect detailed data before, during, and after surgery to identify factors that affect recovery and complications. The goal is to improve risk prediction, persona…
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:03 UTC
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Digital twins could make aorta surgery safer and smarter
Knowledge-focused Recruiting nowThis study gathers medical images and health data from 5000 people who had TEVAR (a type of aorta surgery) to create computer models called digital twins. These models simulate the surgery to help doctors choose the best device and predict problems. The goal is to make planning m…
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:08 UTC
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Aortic disease study seeks to uncover hidden toll on work and Well-Being
Knowledge-focused Recruiting nowThis study tracks 300 adults with aortic disease to measure how their condition impacts quality of life, fatigue, mental health, and ability to work. Researchers will use questionnaires over 12 months to gather data. The goal is to better understand these challenges and help desi…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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New MRI technique could spot hidden heart damage early
Knowledge-focused Recruiting nowThis study will use a new type of cardiac MRI to look at the heart's microscopic structure in 1,000 people—both healthy volunteers and those with various heart conditions. The goal is to see if this advanced imaging can detect early signs of heart damage better than standard test…
Sponsor: The Cleveland Clinic • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Massive heart biobank aims to unlock secrets of aortic disease
Knowledge-focused Recruiting nowThis study is creating a large biobank of blood, DNA, plasma, and tissue samples from 15,000 people with and without heart and aortic diseases. Researchers will use this information to better understand conditions like aortic aneurysm, heart failure, and bicuspid aortic valve. Th…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:24 UTC
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Women's aorta health under the microscope: new study seeks answers
Knowledge-focused Recruiting nowThis study enrolls women aged 50 and older to measure the size of their abdominal aorta using ultrasound. Researchers will also collect health history and look for risk factors that may be unique to women. The goal is to better understand and detect aortic disease in women. No tr…
Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:00 UTC
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Heart changes after aortic repair: new study uses MRI to find out
Knowledge-focused Recruiting nowThis study will use cardiac MRI to track changes in heart structure and function in 40 patients who have had endovascular repair for aortic disease. Researchers will compare heart measurements taken before surgery and again at 6 and 12 months afterward. The goal is to understand …
Sponsor: Lisbon Academic Medical Center - Centro Académico de Medicina de Lisboa • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:06 UTC
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Massive study to unravel genetic mysteries of aortic disease
Knowledge-focused Recruiting nowThis study is gathering 5,000 people with certain gene changes that raise the risk of aortic disease (like aneurysms or dissections). Researchers will track their health over time to see how these genes affect the condition. The goal is to better predict and manage the disease, n…
Sponsor: The University of Texas Health Science Center, Houston • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC