AIDS dementia complex
MONDO:0020689A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Also known as: AIDS dementia, AIDS dementia complex, ADC, ADC - Acquired immune deficiency syndrome dementia complex, AIDS - Acquired immune deficiency syndrome dementia complex, AIDS Dementia, AIDS Dementia Complex, AIDS Encephalopathies
148 clinical trials for this condition and its sub-types.
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AI city halls: could Robot-Run domes cure addiction and homelessness?
Disease control Not yet recruitingThis study will test whether living in a self-contained, AI-managed community (called a Microcity) can improve mental health and reduce addiction in adults with conditions like autism, ADHD, substance use disorders, and behavioral addictions. Up to 1 million participants will liv…
Phase: NA • Sponsor: Veterans Recovery Network Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC
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Can a few support sessions prevent psychiatric readmissions?
Disease control Not yet recruitingThis study tests a short case management program for people who have been involuntarily admitted to a psychiatric hospital. The program, designed with input from people who have experienced coercion, provides up to five sessions with a nurse or social worker starting during the h…
Phase: NA • Sponsor: Stéphane Morandi • Aim: Disease control
Last updated Jun 27, 2026 12:36 UTC
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New program aims to stop elder abuse in dementia caregiving
Prevention Not yet recruitingThis study tests an 8-week program called KINDER, designed to help family caregivers of people with dementia reduce psychological elder abuse and improve the quality of care. The program includes group discussions over Zoom and a self-paced workbook. Researchers will enroll 260 c…
Phase: NA • Sponsor: Case Western Reserve University • Aim: Prevention
Last updated Jun 27, 2026 12:35 UTC
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Can a 5-Week online sleep program help dementia patients and their caregivers rest better?
Symptom relief Not yet recruitingThis study tests whether a virtual cognitive behavioral therapy for insomnia (CBT-I) program, called REPAIR Sleep, can improve sleep and emotional well-being in people with dementia and their live-in caregivers. Over 5 weekly video sessions, participants learn techniques like set…
Phase: NA • Sponsor: Emory University • Aim: Symptom relief
Last updated Jun 27, 2026 12:31 UTC
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Can computer exercises sharpen thinking in mental illness?
Symptom relief Not yet recruitingThis study tests whether a type of cognitive training called Action-Based Cognitive Remediation (ABCR) can improve thinking skills in people with various psychiatric conditions like depression, schizophrenia, anxiety, PTSD, and autism. Participants will complete computer exercise…
Phase: NA • Sponsor: The Royal Ottawa Mental Health Centre • Aim: Symptom relief
Last updated Jun 27, 2026 12:10 UTC
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AI-Powered app aims to ease dementia care decisions
Symptom relief Not yet recruitingThis pilot study will test a digital platform called the Dementia Journey Companion (DJC) that helps people with dementia and their caregivers plan future care. Researchers will enroll 150 participants with mild to moderate dementia living at home or in care facilities. The study…
Phase: NA • Sponsor: University of Bonn • Aim: Symptom relief
Last updated Jun 27, 2026 09:01 UTC
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Can a laser pen calm dementia symptoms? new trial aims to find out
Symptom relief Not yet recruitingThis study tests whether laser acupuncture—using a pen-like device that shines light on specific points on the body—can improve behavioral and psychological symptoms in people with dementia. Sixty participants will receive either real or sham laser treatment three times a week fo…
Phase: NA • Sponsor: China Medical University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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New tool to measure mental health recovery being tested in france
Knowledge-focused Not yet recruitingThis study aims to adapt and validate a French version of the Recovery Assessment Scale (RAS), a questionnaire that measures how people feel about their own recovery from mental health conditions. Researchers will ask 260 adult psychiatric patients in France to fill out the RAS a…
Sponsor: Etablissement Public de Santé Mentale de Metz-Jury • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Can a simple quiz predict brain health in aging? italian study aims to find out
Knowledge-focused Not yet recruitingThis study will test an Italian version of a questionnaire called the dynamic Neurocognitive Adaptation (dNA) scale in 265 older adults, including those with normal aging, mild memory complaints, or dementia. The goal is to see if higher scores on the scale—reflecting more engage…
Sponsor: Neuromed IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC
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New study aims to tackle physical health in mental health wards
Knowledge-focused Not yet recruitingThis study will test a tool called the Health Improvement Profile (HIP) in a mental health inpatient unit. The HIP is a checklist that helps clinicians spot physical health problems like high blood pressure or poor diet in people being treated for mental illness. Researchers will…
Phase: NA • Sponsor: Charles Darwin University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:02 UTC
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Massive study to uncover hidden mental toll of cancer
Knowledge-focused Not yet recruitingThis study aims to better understand psychiatric disorders, thinking problems, and treatment side effects in 2000 cancer patients and their close relatives. Researchers will compare those with and without mental health issues to find patterns and improve care. No new treatments a…
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:04 UTC
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AI toolkit aims to ease pain and distress in dementia patients
Knowledge-focused Not yet recruitingThis study is testing a digital toolkit that uses AI and wearable sensors to assess pain and distress in people with mild to moderate dementia. The goal is to see if the toolkit is easy to use and accurate. If it works, it could help caregivers better understand and respond to th…
Phase: NA • Sponsor: University of Bonn • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:02 UTC
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Can better communication in occupational therapy improve client care? new study aims to find out.
Knowledge-focused Not yet recruitingThis study will check how much psychiatric clients know about occupational therapy (OT) and whether their expectations are realistic. It will also evaluate how well OT interns explain health information and conduct interviews. Researchers will develop new tools to measure these s…
Sponsor: Chang Gung Memorial Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:10 UTC