AIDS dementia complex
MONDO:0020689A neurologic condition associated with the ACQUIRED IMMUNODEFICIENCY SYNDROME and characterized by impaired concentration and memory, slowness of hand movements, ATAXIA, incontinence, apathy, and gait difficulties associated with HIV-1 viral infection of the central nervous system. Pathologic examination of the brain reveals white matter rarefaction, perivascular infiltrates of lymphocytes, foamy macrophages, and multinucleated giant cells. (From Adams et al., Principles of Neurology, 6th ed, pp760-1; N Engl J Med, 1995 Apr 6;332(14):934-40)
Also known as: AIDS dementia, AIDS dementia complex, ADC, ADC - Acquired immune deficiency syndrome dementia complex, AIDS - Acquired immune deficiency syndrome dementia complex, AIDS Dementia, AIDS Dementia Complex, AIDS Encephalopathies
7 clinical trials for this condition and its sub-types, 6 tagged with AIDS dementia complex itself.
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HIV memory mystery: even controlled virus may harm the brain
Knowledge-focused Recruiting nowThis study looks at why some people with HIV who have very low virus levels in their blood still develop thinking and memory problems. Researchers will follow 1,150 participants—including healthy volunteers—for up to 10 years, using brain scans, blood tests, and spinal fluid samp…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Sep 18, 2026 00:00 UTC
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New brain scans may uncover hidden HIV damage
Knowledge-focused Recruiting nowThis study uses special PET scans to measure brain synapse density in people with HIV who are on effective treatment. Researchers want to understand why some still develop thinking or memory problems. They will compare 70 participants (with and without HIV) over two years using b…
Phase 1/2 • Sponsor: Yale University • Aim: Knowledge-focused
Last updated Aug 20, 2026 00:00 UTC