Acute myocarditis

This Phase 3 trial tests whether colchicine, an anti-inflammatory drug, can reduce heart scarring and prevent complications in 300 people with acute myocarditis (heart inflammation). Participants receive colchicine or a placebo for six months alongside standard care. The goal is …

This clinical trial is testing whether a 3-week course of ibuprofen can reduce heart scarring better than standard acetaminophen in people hospitalized with acute myocarditis (heart muscle inflammation). The study will enroll 150 adults with mild cases (normal heart pumping funct…

This phase 3 trial tests whether abatacept (Orencia) can reduce major heart complications in cancer patients who develop myocarditis (heart inflammation) from immune checkpoint inhibitors. About 390 hospitalized adults will receive either abatacept or placebo plus standard care. …

This study is testing whether a special PET/CT scan using a tracer called PentixaFor can accurately detect acute inflammation in the heart. It focuses on three conditions: heart transplant rejection, cardiac sarcoidosis, and myocarditis caused by cancer drugs. Researchers will en…

This study is looking at whether advanced heart imaging, especially cardiac MRI, can help identify the cause of cardiomyopathy and predict risks like death or heart failure in a diverse group of patients. The research focuses on adults in the Bronx, including many from Hispanic a…

This study is a large registry that will collect information from 10,000 adults who undergo exercise echocardiography (a heart ultrasound during exercise) as part of their regular care. The goal is to better understand how the heart works during exercise in people with various he…

This study is building a large online registry of 10,000 adults with cardiomyopathy or myocarditis, plus those with a strong family history. Researchers will track participants over time to see how many experience serious events like heart failure, dangerous heart rhythms, or dea…

This study aims to improve how doctors predict the risk of sudden cardiac death or heart failure in people with inherited heart diseases. Researchers will use artificial intelligence to analyze data from 1,000 participants, including medical history, ECGs, imaging, genetic tests,…

This study follows 1500 people who already have an implantable cardioverter-defibrillator (ICD) to prevent sudden cardiac death. Researchers will track heart function, genetics, and blood markers to find better ways to predict who is at highest risk. The goal is to improve how do…

This study looks at heart tissue samples from 216 adults who already need a biopsy as part of their care. Researchers want to find unique molecular patterns in different heart conditions, including after a heart transplant. The goal is to improve how these diseases are diagnosed …