Acute chest syndrome
MONDO:0005632A vaso-occlusive crisis of the pulmonary vasculature occurring in patients with sickle cell disease. It is characterized by the presence of a new radiodensity on a chest radiograph accompanied by fever, cough, sputum production, dyspnea, or hypoxia.
Also known as: ACS
30 clinical trials for this condition and its sub-types.
Follow this condition to get notified about new trialsBroader categories
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Experimental antibody IC14 tested in rare heart condition
Disease control CompletedThis early-phase trial tested IC14 (atibuclimab), an antibody that targets inflammation, in one person with arrhythmogenic cardiomyopathy (ACM), a rare heart muscle disease that can cause dangerous heart rhythms. The study measured safety, blood markers of inflammation, and heart…
Phase 1/2 • Sponsor: Implicit Bioscience • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Daily vitamin d may slash lung risks in kids with sickle cell disease
Disease control CompletedThis study tested whether taking vitamin D every day could reduce lung complications in children and teens with sickle cell disease. Lung problems like infections, asthma attacks, and acute chest syndrome are major causes of illness and death in this condition. Researchers gave d…
Phase 2 • Sponsor: Columbia University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Can a quick ultrasound spot a deadly lung complication in sickle cell kids?
Diagnosis CompletedThis study looks at whether a bedside ultrasound (POCUS) can help doctors quickly diagnose acute chest syndrome in children and young adults with sickle cell disease. Researchers will enroll 30 hospitalized patients aged 0-25 to see if the ultrasound is practical and reliable com…
Sponsor: Indiana University • Aim: Diagnosis
Last updated Sep 04, 2026 00:00 UTC
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New magnetic heart scanner could speed up ER heart attack diagnosis
Diagnosis CompletedThis study tested a portable, unshielded magnetocardiography (MCG) device in the emergency department to see if it could reliably detect heart attacks. 124 patients with symptoms of acute coronary syndrome participated. The main goal was to see if the device could collect usable …
Sponsor: SB Technology, Inc. • Aim: Diagnosis
Last updated Jun 27, 2026 07:55 UTC
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Early heart scans may help kidney patients live longer and delay dialysis
Knowledge-focused CompletedThis study reviewed medical records of 139 people with advanced chronic kidney disease who had a heart attack. Researchers wanted to see if getting a coronary angiogram (a special X-ray of the heart arteries) soon after the heart attack was linked to living longer and needing dia…
Sponsor: Chulalongkorn University • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:01 UTC
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Hidden gene changes may raise heart risk even after quitting smoking
Knowledge-focused CompletedThis completed study looked at 1029 patients who had a heart attack or unstable angina and quit smoking. Researchers checked for certain gene mutations (called CHIP) in their blood. They wanted to see if these mutations are linked to a higher chance of future heart problems, like…
Sponsor: Shenyang Northern Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:27 UTC