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Acute chest syndrome

MONDO:0005632

A vaso-occlusive crisis of the pulmonary vasculature occurring in patients with sickle cell disease. It is characterized by the presence of a new radiodensity on a chest radiograph accompanied by fever, cough, sputum production, dyspnea, or hypoxia.

Also known as: ACS

52 clinical trials for this condition and its sub-types.

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Broader categories

Disease (618) Lung disorder (225) Respiratory system disorder (127) Syndromic disease (24) Acute disease (18) Lower respiratory tract disorder (16) Human disease (14) Disease by body system or component (0)

Trials to join now! 24 Not yet recruiting 9 Not yet finished but already full! 5 Completed 13 Terminated 1

Breathing machine may ease lung risk for kids with sickle cell

Prevention Terminated

This study tested whether a non-invasive breathing machine (ventilation) could prevent acute chest syndrome, a serious lung complication, in children with sickle cell disease who were hospitalized for severe pain. The standard prevention is spirometry, which requires active deep …

Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Prevention

Last updated Jun 27, 2026 09:04 UTC