Breathing machine may ease lung risk for kids with sickle cell
NCT ID NCT01501643
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a non-invasive breathing machine (ventilation) could prevent acute chest syndrome, a serious lung complication, in children with sickle cell disease who were hospitalized for severe pain. The standard prevention is spirometry, which requires active deep breathing, but pain and sleep can make that hard. The trial planned to compare the two approaches in children aged 6–20, but it was stopped early after enrolling only 6 participants, so no firm conclusions can be drawn.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- non-invasive positive pressure ventilation (device)
- What this could lead to
- If it worked, this approach could offer a more comfortable way to prevent a serious lung complication in children with sickle cell disease during painful crises.
- What could go wrong
- The trial was terminated early with only 6 participants, so we have very little data. It is unclear if the device is better than standard care, and results may not apply broadly.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
-
Hôpital Necker - Enfants Malades Hospital
Paris, 75015, France
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