Acute chest syndrome

This study tests whether dapagliflozin, a drug typically used for diabetes, can lower inflammation in the heart arteries of people who recently had a heart attack but do not have diabetes or heart failure. About 110 participants will receive either the drug plus standard care or …

This study tests whether a short course of the antibiotic rifaximin can improve how well the blood thinner ticagrelor works in people who have had a heart attack. The idea is that unhealthy gut bacteria may interfere with the drug, and clearing them out could help prevent future …

This study is testing a new tool called UFR, which uses ultrasound images to measure blockages in heart arteries during a heart attack. Currently, the most accurate method requires patients to return 30 days later for a second invasive procedure. The study will enroll 200 heart a…

This study compares a new, simpler nerve block method to the traditional one for people having lung surgery with a camera (VATS). The goal is to see if the new method works just as well for pain control and helps patients recover faster. About 200 adults will be randomly assigned…

This study looks at whether watching cartoons or listening to breath-synchronized interactive stories can help children aged 6-9 feel less afraid and more comfortable while using a nebulizer for breathing medication. About 96 children with respiratory conditions will be randomly …

This study tests if applying cold (cryotherapy) to the wrist before a blood draw from the artery can reduce pain. It involves 258 adults with chronic respiratory diseases who need this test. The goal is to find a simple, drug-free way to make the procedure less painful.

This study tests whether adding lidocaine, a numbing medicine, to standard pain treatment can lower the amount of strong opioids needed during severe sickle cell pain crises. About 104 adults with sickle cell disease who are in the intensive care unit for a pain crisis will take …

This study tests whether awake prone positioning (lying on the stomach while awake) can help sickle cell patients with severe acute chest syndrome in the ICU. The approach aims to improve oxygen levels and breathing by evening out air flow in the lungs. Fifteen adults will be enr…

This study will follow 645 older adults (65+) who come to the hospital with a heart attack. Researchers want to see if frailty—a state of reduced strength and energy—affects how doctors treat them and whether they have serious problems like death or another heart event within 30 …