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127005 trials found · Page 6025 of 6351
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COPD study aims to unlock clues behind immune cell drop during severe attacks
Knowledge-focused Recruiting nowThe goals of this observational study are to identify factors independently associated with admission eosinopenia in patients with a severe exacerbation of chronic obstructive pulmonary disease (COPD) and to determine when blood eosinophil count (BEC) will recover to baseline sta…
Sponsor: Northumbria Healthcare NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC
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Heart surgery study questions routine use of ultrasound probe
Knowledge-focused CompletedThis goal of this study is to better understand when and where intraoperative transesophageal echocardiography (TEE) should (or should not) be used during coronary artery bypass graft (CABG) surgeries.
Sponsor: University of Pennsylvania • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:32 UTC
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Which blade size works best for intubation? large study seeks answers
Knowledge-focused CompletedEndotracheal intubation is a frequent procedure in the operating room but optimal Macintosh blade size remains unknown to date.
Sponsor: University Hospital, Clermont-Ferrand • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:01 UTC
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Sepsis clot study reveals hidden danger
Knowledge-focused CompletedImpaired fibrinolysis in septic patients is associated with worse outcome. The present study investigates fibrinolysis shutdown in septic patients, defined as prolonged ClotPro® TPA lysis time at 30 minutes. The TPA lysis time reference range is established in a cohort of healthy…
Sponsor: Policlinico Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:05 UTC
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Cochlear implant Users' speech skills tracked over time
Knowledge-focused CompletedThis is a retrospective study designed to collect long-term speech perception results for cochlear implants recipients using electro-acoustic-stimulation as measured in the clinical routine and to confirm the performance of sound processors associated with acoustic earhooks.
Sponsor: Advanced Bionics AG • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Drain or no drain? new study aims to cut unnecessary tubes after gallbladder surgery
Knowledge-focused CompletedThis study looks at when surgical drains are truly needed after laparoscopic gallbladder removal (laparoscopic cholecystectomy). Drains are sometimes placed during surgery to prevent fluid buildup or infection, but many studies show they are not always necessary. We reviewed 559 …
Sponsor: University of Baghdad • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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Gum disease could throw off your Body's daily rhythm, study finds
Knowledge-focused CompletedThis observational study aims to investigate whether periodontal inflammation is associated with alterations in the expression of circadian clock-related genes and proteins in gingival tissues. Circadian rhythms regulate many biological processes, including immune responses and i…
Sponsor: Inonu University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:10 UTC
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Can zapping the brain help you learn faster?
Knowledge-focused CompletedThe purpose of this study is to compare the effectiveness of different repetitive Transcranial Magnetic Stimulation protocols for enhancing motor learning in healthy peolple.
Sponsor: Neuron, Spain • Aim: Knowledge-focused
Last updated Jun 26, 2026 13:02 UTC
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Helmet or facemask: which breathing aid wins for low oxygen?
Knowledge-focused CompletedThe optimal noninvasive management of acute hypoxemic respiratory failure is debated. Helmet noninvasive ventilation may be more effective than facemask noninvasive ventilation for these patients. Putatitve benefits of helmet use are the possibility to apply significantly higher …
Sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC
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Do graphic warning labels on alcohol deter drinkers? new study investigates
Knowledge-focused CompletedThe goal of this study is to determine the effectiveness of pictorial warning labels (PWLs) featuring narrative (vs. non-narrative) content in communicating the cancer risk of alcohol. Participants will be randomized to view either three narrative or non-narrative PWLs. Key outco…
Sponsor: University of Connecticut • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Hidden joint pain in nursing homes revealed
Knowledge-focused CompletedThe goal of this observational study is to investigate the prevalence of joint complaints in nursing home residents with and without dementia. Primary objective: Number of tender or swollen joints. Secondary objectives: 1. Only when it is possible for the nursing home resident…
Sponsor: Maastricht University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:53 UTC
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Simple urine test may spot kidney risk in spina bifida
Knowledge-focused Recruiting nowThe aim of the study is to investigate known urinary biomarkers in order to determine whether they can be predictive of a risk of damage to the upper urinary tract and therefore the kidneys in patients with spina bifida. The risk of damage to the upper urinary tract can be calcul…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Family fit app aims to get parents and kids moving together
Prevention CompletedThe overall aim of this study is to test the acceptability and usability of a mobile application (app) for family-based physical activity and weight gain prevention among parent/guardian and child (ages 9-12 years) dyads.
Sponsor: University of Florida • Aim: Prevention
Last updated Jun 27, 2026 14:02 UTC
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Vaccine antibody check: how long does protection last?
Knowledge-focused Stopped earlyThe goal of this follow-up study is to investigate the persistence of the immune response induced by the GBS-NN/NN2 vaccine in women who have participated in study MVX0002, and/or in study MVX0003 with GBS-NN/NN2 vaccine and received 1, 2 or 3 doses of GBS-NN/NN2. The main questi…
Sponsor: Minervax ApS • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Low-Dose anesthesia may change how pain impacts memory
Knowledge-focused CompletedThe purpose of this study is to determine the effects of acute pain on long-term memory and conditioned physiologic responses in the presence and absence of low dose sevoflurane. Functional magnetic resonance imaging will be used to identify the neural correlates of these phenome…
Early phase 1 • Sponsor: Keith M Vogt • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Calf muscle strength under scrutiny in ACL injury study
Knowledge-focused Recruiting nowThe goal of this prospective, cross-sectional study is to test the strength of the soleus muscle in participants who have a ACL tear confirmed by MRI. Previous studies have shown that the soleus muscle, which one of the muscles situated in the calf, decreases mechanical loading o…
Sponsor: University of Liverpool • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC
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No new drug: study tracks bleeding in hemophilia b patients on usual care
Knowledge-focused OngoingThis study is focused on males who have Hemophilia B and who need regular preventive treatment with factor IX protein (FIX) replacement therapy to prevent and also to control their bleeding events. The aim of the study is to gather at least 6 months of information on bleeding eve…
Sponsor: Regeneron Pharmaceuticals • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Honey and nuts may beat sugar for blood sugar control
Symptom relief OngoingThe purpose of this research is to compare two snacks, one with honey and nuts and the other with sugar and nuts, on glucose levels before and after eating these snacks. The investigators hypothesize that honey and nuts will have an additive effect on the reduction of postprandi…
Sponsor: USDA, Western Human Nutrition Research Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:00 UTC
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Simulation labs boost nursing skills, study finds
Knowledge-focused CompletedThe aim of this study is to determine the effect of integrated education, combining clinical practice and simulation laboratory training, on the competence of second-year undergraduate nursing students. This research is designed as a multi-crossover quasi-experimental randomized …
Sponsor: Duzce University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:00 UTC
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Could your aspirin be failing you? trinidad study investigates
Knowledge-focused CompletedAspirin's beneficial effect is mediated via the inhibition of arachidonic acid (AA) activation of platelets. It is detected by demonstrating a decrease in platelet function and/or a decrease in prostaglandin metabolites. Besides inhibiting the formation of thromboxane A2 from ara…
Phase 2 • Sponsor: The University of The West Indies • Aim: Knowledge-focused
Last updated Jun 26, 2026 16:41 UTC