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This study wants to obtain more information regarding the patient's concerns since concerns of the patient about the procedure is found as a predictor for the development of chronic post-surgical pain. This step is crucial in translating early identification of a high-risk popula…

The purpose of this study is to evaluate the changes in the stiffness of the masseter muscle (a jaw muscle) before and after two types of treatment: applying commercial heat pads or using a commercial massage gun. We will measure the muscle stiffness on the surface of the muscle…

This is a randomized, double-blind, placebo-controlled, single ascending dose (SAD) study of SYH2070 injection when administered subcutaneously to healthy subjects.

Forward head posture is commonly observed among university students and may influence cervical sensorimotor function and physiological responses during functional activities. The purpose of this observational cross-sectional study is to examine the association between forward hea…

This is an exploratory, international, prospective, interventional, multicenter clinical investigation that will take place in 1 Hong Kong site and 3 French sites and 309 adults patients will be included. The study objective is to assess the LSM reproducibility between the FibroS…

This study will develop a protocol for remote human milk collection for use in gene expression research through application of ribonucleic acid (RNA) preservation reagents. The investigators hypothesize that addition of preservation reagents will preserve RNA in human milk, facil…

The goal of this observational study is to observe the effectiveness of pain management strategies in patients with chronic cancer pain presenting to pain management clinic at Aga Khan University. The main question\[s\] it aims to answer are: * What is the overall effectiveness…

Children with functional constipation are a large patient group that not only needs to seek care at primary healthcare centers and pediatric clinics, but many of the visits received at the emergency department are related to symptoms of constipation. The personal suffering, physi…

Given the pervasiveness of Pediatric Obesity, it is imperative to understand its pathophysiology and develop alternative strategies to reverse this condition. Herein, investigators propose to elucidate the interaction between colonic fermentation and insulin resistance in modulat…

Children receiving chronic haemodialysis are typically treated with dialysis machines designed for adult patients. As a result, some devices do not allow the ideal blood or dialysate flow rates to be set for paediatric use. In addition, the optimal dialysate-to-blood flow ratio f…

This is a randomized, single-blind clinical trial that will include healthy individuals between the ages of 19 and 24. Participants with previously diagnosed neurological and/or psychiatric disorders, a history of traumatic brain injury, use of psychoactive substances or medicati…

Translation of OHIP-CP questionnaire in Hindi language will be done. Patients recruited will undergo clinical examination and recording of periodontal parameters (Pocket probing Depth and Clinical Attachment Loss) will be recorded to determine stage and grade of periodontitis. Pa…

This post-market study is being conducted to generate safety and performance data on the SiteRite 9 System. The data will be utilized to support regional registrations (for example, EU MDR), and document any unforeseen residual risks.

The distribution- and anchor-based methods will be used to estimate the Minimal Important Difference (MID) of the OHIP-P-HIN. Two established distribution-based approaches, the standardized effect size (ES) and standardized response mean (SRM) will be calculated. The ES is calcul…

The goal of this clinical trial is to learn the effects of stable and unstable resistance training on physical fitness, kidney function and blood lipid tests in healthy young male volunteers. The main questions it aims to answer are: * Do both stable and unstable resistance trai…

To assess subject-centric real-world evidence of QoL outcomes in subjects enrolled in the global Phase 3 AU-011-301 clinical trial.

This study aims to compare the effects of functional and conventional inspiratory muscle training (IMT) on post-exercise muscle deoxygenation in individuals with Chronic Obstructive Pulmonary Disease (COPD). Participants will complete both training modalities on separate days. A …

This study aims to understand how different types of fatigue affect balance and reaction time, proprioception, and fine motor in healthy young adults. Fatigue is a common experience in daily life and can arise from physical activity or prolonged mental effort. The study seeks to …

This study in healthy volunteers aims to compare blood levels and side effects after administration of different formulations of AZD6234. This study will take place at one site in Nottingham, United Kingdom, and will enrol 21 healthy men and women aged 18-55 years.

This is a non-randomized, open-label, parallel, single-dose study to evaluate the pharmacokinetic profile of olverembatinib in participants with normal or impaired liver function.