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127005 trials found · Page 5349 of 6351
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New study tests if video laryngoscopy makes tracheostomy safer
Knowledge-focused Recruiting nowWhen preparing an ICU patient for percutaneous dilational tracheostomy, correct positioning of the endotracheal tube is important. During the procedure, it is possible to puncture the cuff. Tracheal tube cuff puncture can lead to failure of ventilation, loss of positive end-expir…
Sponsor: Hospital Clinico Universitario de Santiago • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:24 UTC
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Infection risk after aortic repair: what the data show
Knowledge-focused Stopped earlyThe infection rate of thoracic endovascular aortic repair (TEVAR) is unknown due to a lack of epidemiological data. The rate currently available comes from researches conducted decades ago, when open surgery was the standard of care. Because of the potentially fatal consequences …
Sponsor: First Affiliated Hospital of Zhejiang University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:51 UTC
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MRI and AI join forces to track spine disease activity
Knowledge-focused Recruiting nowThis study aims to further improve and expand the WB-MRI imaging evaluation cohort of axSpA patients to complete dynamic follow-up and condition assessment. Based on the WB-MRI features, the association of WB-MRI signs with disease activity, inflammation, and structural damage wi…
Sponsor: The First Affiliated Hospital with Nanjing Medical University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:57 UTC
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Does anesthesia flow rate affect inflammation in obesity surgery?
Knowledge-focused CompletedThis retrospective observational study aimed to compare the effects of low-flow and standard-flow sevoflurane anesthesia on perioperative inflammatory responses in patients undergoing laparoscopic sleeve gastrectomy for obesity. Data were obtained from the anesthesia and laborato…
Sponsor: Adana City Training and Research Hospital • Aim: Knowledge-focused
Last updated Aug 29, 2026 00:00 UTC
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Can shedding pounds sharpen your mind? huge study investigates
Knowledge-focused By invitation onlyStudy is designed to screen psychological cognitive baseline and retention/improvement after weight loss surgery.
Sponsor: University of California, Davis • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:02 UTC
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New asthma treatment for kids who Don't respond to standard steroids?
Disease control Stopped earlyMost children with asthma have concurrent atopy (allergic inflammation), which is associated with an improved response to ICS. However, the absence of an atopic phenotype is associated with a poorer ICS response, leaving clinicians with limited treatment options. The nonatopic as…
Phase 2 • Sponsor: Nemours Children's Clinic • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Is this constipation pill safe for pregnant women? new study investigates
Knowledge-focused OngoingThis study will collect information on pregnant women diagnosed with constipation from the two large health care insurance claims records. It will include the following groups: * Those who took prucalopride. * Those who took other medicines for constipation. * Those who did not…
Sponsor: Takeda • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Which laser eye surgery gives better vision? new study compares SMILE and LASEK
Knowledge-focused Completed1. Study the changes in subjective visual quality, contrast sensitivity, and total ocular aberrations of patients with low-to-moderate myopia after SMILE and LASEK surgeries at different age groups; 2. Evaluate the effects of SMILE and LASEK surgeries on the visual conduction pat…
Sponsor: yuhao shao • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC
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Neck pain relief: do added numbing drugs help?
Symptom relief CompletedThis study aims to evaluate the efficacy of local anesthetic drugs in cervical epidural injections for chronic neck pain.
Sponsor: Mustafa Kurçaloğlu • Aim: Symptom relief
Last updated Jun 27, 2026 09:06 UTC
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New wash aims to stop infections after bone surgery
Prevention OngoingA taurolidine-based antimicrobial solution, was evaluated for its safety and efficacy in preventing infections associated with prosthetic materials, such as joint replacements, plates, nails, and screws. This prospective observational study compared Taurolidine to infection rates…
Sponsor: University of Kiel • Aim: Prevention
Last updated Jun 27, 2026 08:12 UTC
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Brain training via telehealth shows promise for veterans battling depression and suicide risk
Symptom relief CompletedDespite large-scale, nationwide efforts to better address suicidal behavior in Veterans at high risk, the development of interventions that target some of the key risk factors associated with suicide remains limited. This study aims to collect pilot data to test feasibility/accep…
Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 08:14 UTC
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Blood test scores may reveal heart attack risk
Knowledge-focused CompletedIt is well known that malnutrition is a prognostic risk factor in chronic heart failure (CHF). Weight loss and the development of cardiac cachexia are associated with poor prognosis in CHF. However, objective indices such as the Prognostic Nutrition Index (PNI) and Controlling Nu…
Sponsor: Muğla Sıtkı Koçman University • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:00 UTC
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Parkinson's Patients' hospital stays under the microscope
Knowledge-focused CompletedThe goal of this observational study is to investigate the causes of hospitalisation via emergency services in patients with degenerative parkinsonian syndromes. All causes of hospital admission through the emergency department among patients with Parkinson's-related disorders w…
Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Knowledge-focused
Last updated Jun 27, 2026 09:08 UTC
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Lasers vs. needles: which root canal hurts less?
Symptom relief CompletedThe aim of this study is to evaluate in vivo the post operative pain after laser root canal treatment in necrotic teeth in an evidence-based clinical trial. The null hypothesis being tested is that there is no difference in post operative pain between conventional irrigation and …
Phase 2 • Sponsor: Future University in Egypt • Aim: Symptom relief
Last updated Jul 02, 2026 00:00 UTC
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Spinal tumor surgery under the microscope: what really happens?
Knowledge-focused OngoingIntradurale spinal tumors are rare neoplastic lesions that involve the spinal cord and surrounding structures and may cause neurological symptoms such as pain, motor deficits, sensory disturbances, and sphincter dysfunction. Surgical resection is often the primary treatment when …
Sponsor: Azienda Ospedaliera SS. Antonio e Biagio e Cesare Arrigo di Alessandria • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:01 UTC
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Gut check: could your Child's microbiome predict diabetes?
Knowledge-focused Recruiting nowTo investigate in a prospective way changes in Mucosal-Associated Invariant T (MAIT) cells frequency, phenotype and function in link with the gut microbiota, gut integrity and the presence of Coxsackie virus B in two cohorts of pediatric patients: patients with a high genetic ris…
Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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Can measuring donor vessel damage boost transplant success?
Knowledge-focused Recruiting nowThe study aims the assessment of endothelial glycocalyx (EG) degradation in deceased organ donors. There is a lack of organs for the transplantation program. By the description of the EG status, we can open room for organ optimization before transplantation and improve the organ …
Sponsor: University Hospital Hradec Kralove • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Digital twin predicts muscle gains: a new era for personalized fitness?
Knowledge-focused CompletedBackground: Muscular strength training interventions have long been a cornerstone in the prevention, non-surgical management and rehabilitation of the entire spectrum of musculoskeletal injuries and diseases. The key goal of strength training, especially during rehabilitation, is…
Sponsor: Silvio Lorenzetti • Aim: Knowledge-focused
Last updated Aug 14, 2026 00:00 UTC
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Insulin resistance score may predict stent failure
Knowledge-focused CompletedBased on previous studies on insulin resistance and cardiovascular diseases, we believe that the insulin resistance metabolic score also has certain predictive value for the prognosis of in-stent restenosis after coronary stent implantation. The main purpose of this study is to e…
Sponsor: Qilu Hospital of Shandong University • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC
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Could probiotic pasta help fight obesity?
Disease control CompletedThis study aims to investigate the effects of daily consumption for 4 weeks of a probiotic durum wheat pasta vs a conventional durum wheat pasta without probiotics on fasting metabolic parameters and inflammatory status, on gut permeability and functionality, on daily energy inta…
Sponsor: Federico II University • Aim: Disease control
Last updated Jun 27, 2026 14:01 UTC