Zhejiang University

This phase 2 trial tests a chemotherapy-free combination of two drugs, fulzerasib and cetuximab N01, given before surgery to people with a specific genetic subtype of colorectal cancer (KRAS G12C mutation). The goal is to shrink tumors and improve outcomes while avoiding the side…

This early-phase study tests a new treatment called C-CAR031 for people with advanced liver cancer that has not responded to standard therapies. C-CAR031 uses a patient's own immune cells, modified to better target and attack cancer cells. The trial will enroll 72 participants to…

This study tests whether a combination of targeted drugs (cetuximab beta and fruquintinib) with or without immunotherapy can control advanced colorectal cancer without traditional chemotherapy. About 70 people with a specific genetic type (RAS/BRAF wild-type) will receive these d…

This study tests a treatment called CD19 CAR-T therapy for people newly diagnosed with a fast-growing type of blood cancer called high-risk large B-cell lymphoma. The therapy uses a patient's own immune cells, modified to better attack cancer cells. The main goal is to see how ma…

This early-stage study tests a new treatment called IL-5 CAR-T cell therapy for people with a rare and hard-to-treat blood cancer called eosinophilic leukemia. The therapy uses a patient's own immune cells, modified to target and attack cancer cells. The main goals are to check s…

This early-phase study tests a new treatment called Meta10-19 for people with moderate to severe systemic lupus erythematosus (SLE). The therapy uses a patient's own immune cells, modified to better target and destroy faulty B cells that drive the disease. The main goals are to f…

This early-stage trial is testing a new treatment called CNCT19 CAR-T cells for people with advanced liver cancer that cannot be removed by surgery or has come back after other treatments. The therapy uses a patient's own immune cells, modified to target cancer cells. The main go…

This early-phase study tests SYNCAR-100, a type of cell therapy (CAR-T), in 16 adults with CD19-positive B-cell acute lymphoblastic leukemia that has come back or not responded to standard treatment. Participants receive four weekly injections, then are followed for safety and tu…

This early-phase trial is testing a new gene therapy called KSV01 for patients with B-cell acute lymphoblastic leukemia that has come back or not responded to standard treatment. The study will enroll 30 adults aged 18 to 80 to check if the treatment is safe and tolerable, and to…

This early study tests a new treatment for advanced liver cancer that has not responded to standard therapies. It uses the patient's own immune cells, modified to target a protein called GPC3 found on cancer cells. The main goals are to check safety and find the right dose, while…

This study tests a treatment called CD19 CAR-T cells in adults with a specific type of acute lymphoblastic leukemia (ALL) that has the Philadelphia chromosome. The therapy uses a patient's own immune cells, modified to target and kill leukemia cells. The main goal is to see if th…

This early-stage study tests a new treatment called UCLH80-1, which uses specially engineered immune cells (CAR-T cells) to target a protein called CDH17 found on many solid tumors. The study includes up to 36 people with advanced cancers like colorectal, stomach, pancreatic, or …

This study is for people with a certain type of locally advanced rectal cancer (pMMR/MSS) that often doesn't respond well to immunotherapy alone. The trial combines an immunotherapy drug (serplulimab) with chemotherapy (CAPEOX) and an anti-inflammatory drug (celecoxib) to see if …

This study tests if giving chemotherapy directly into the artery that feeds the stomach tumor, along with an immunotherapy drug, works better than standard IV chemo plus immunotherapy for locally advanced stomach cancer. About 190 adults with stage 3 stomach cancer will be random…

This study tests a new drug combination (HRS-4642, nimotuzumab, and chemotherapy) as a first treatment for people with advanced pancreatic cancer that has a specific KRAS G12D mutation. About 32 participants will receive the combination to see how many respond. The goal is to con…

This study tests a new drug called IBI343 combined with standard chemotherapy for people with advanced pancreatic cancer that has a specific marker (CLDN18.2). The goal is to see if the combination is safe and works better than chemo alone. About 64 adults will take part, and the…

This study compares a newer, less invasive surgery (LISH) that saves part of the colon to the standard surgery (TRH) for people with colon cancer in specific areas. The goal is to see if the newer surgery leads to better long-term survival without the cancer coming back. About 56…

This study tests a new combination of drugs (HRS-4642, nimotuzumab, and chemotherapy) in 40 people with a specific type of pancreatic cancer that has a KRAS G12D mutation and is borderline removable. The goal is to see if the treatment can shrink the tumor enough for surgery and …

This study will enroll 60,300 people aged 45-74 who are at average risk for colorectal cancer. Participants will be randomly assigned to one of three screening methods: colonoscopy, a stool test (FIT), or a stool test plus a blood test. The goal is to see if the simpler tests are…

This study tests a new device called the COMBO Endoscopy Oropharyngeal Airway in 580 obese patients undergoing gastrointestinal endoscopy under sedation. The device combines oxygen delivery, airway support, and monitoring to prevent low oxygen levels, a common risk in these patie…

This study tests whether adding a gentle electrical acupoint stimulation (TEAS) to a standard three-drug anti-nausea regimen can further reduce vomiting after laparoscopic surgery. Researchers will compare active TEAS to a sham (fake) version in 780 women at high risk for postope…

This study tests whether a rectal indomethacin suppository given right after surgery can prevent or reduce bladder discomfort caused by a urinary catheter in men undergoing laparoscopic radical prostatectomy. About 130 participants will be randomly assigned to receive either the …

This study tests whether a new device that combines a bite block, oxygen tube, and airway support can prevent dangerously low oxygen levels in severely obese patients during sedated endoscopy. About 410 adults with a BMI of 35 or higher will be randomly assigned to receive either…

This study tests whether a high-flow nasal cannula (a device that delivers warm, moist oxygen) can prevent low oxygen levels during sedated gastrointestinal endoscopy in people at high risk for obstructive sleep apnea. About 600 adults with a STOP-Bang score of 5 or higher will b…

This study looks at whether a high-flow nasal cannula (a device that delivers warm, moist oxygen at high rates) can reduce the chance of dangerously low oxygen levels during sedated gastrointestinal endoscopy in critically ill patients. About 450 adults with serious health condit…

This study looks back at 1,200 people who had a breathing tube placed during surgery to find out how often voice box injury happens and what makes it more likely. Researchers will check medical records and call patients to see if they had hoarseness or other throat problems after…

This study aims to develop a simple tool to predict whether a person's stomach will still have food or liquid in it before a sedated endoscopy. Having a full stomach during sedation raises the risk of serious complications like choking. Researchers will study 5,000 adults to iden…