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New Colon-Sparing surgery could improve cancer outcomes

NCT ID NCT05923255

Disease control Sponsor: Zhejiang University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares a newer, less invasive surgery (LISH) that saves part of the colon to the standard surgery (TRH) for people with colon cancer in specific areas. The goal is to see if the newer surgery leads to better long-term survival without the cancer coming back. About 568 adults with colon cancer will be randomly assigned to one of the two surgeries and followed for 3 years.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 568 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2023

Expected to finish

May 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 75 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age between 18-75 years old 2. ASA classification ≤III 3. Colon adenocarcinoma confirmed by endoscopy and pathological biopsy 4. Enhanced abdominal CT indicating the primary lesion is located in the hepatic flexure of the colon or proximal transverse colon (proximal 1/3 of the transverse colon) 5. Preoperative clinical staging: TanyNanyM0 6. Patients able to understand the study protocol, willing to participate in the research, and providing written informed consent Exclusion Criteria: 1. Preoperative examination indicates synchronous multiple primary colorectal cancers or other diseases requiring bowel segment resection 2. Preoperative imaging or intraoperative exploration reveals: 1) tumor involving surrounding organs requiring combined organ resection; 2) presence of distant metastasis; 3) inability to perform R0 resection; 4) fused and fixed lymph nodes at the root of the ileocolic vessels 3. Additional radical surgery following Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD) procedures 4. History of any other malignant tumor within the last 5 years or familial adenomatous polyposis, except for cured in situ cervical cancer, basal cell carcinoma, papillary thyroid carcinoma, or skin squamous cell carcinoma 5. Presence of bowel obstruction, bowel perforation, or intestinal bleeding requiring emergency surgery 6. Patients unsuitable for or unable to tolerate laparoscopic surgery 7. Pregnant or lactating women 8. Patients with a history of psychiatric disorders 9. Patients who have received neoadjuvant therapy prior to surgery 10. Patients deemed unsuitable for the study by MDT discussion 11. Patients unable to understand the study's conditions and objectives, and refusing to sign informed consent.

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Conditions

The condition(s) this trial relates to.

hepatic flexure cancer transverse colon cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Hepatic flexure colon cancer Proximal transverse colon cancer

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    29 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Beijing Cancer Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100000, China

  • Cancer Hospital Academy of medicine Scenice

    RECRUITING

    Beijing, Beijing Municipality, China

  • Changhai Hospital of Shanghai

    RECRUITING

    Shanghai, Shanghai Municipality, 200433, China

  • Fudan University Shanghai Cancer Center

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Fujian Cancer Hospital

    RECRUITING

    Fuzhou, Fujian, 350001, China

  • Fujian Hospital Medical Union University

    RECRUITING

    Fuzhou, Fujian, 350001, China

  • Guangdong Second Provincial General Hospital

    RECRUITING

    Guangzhou, Guangdong, 510317, China

  • Jiangsu province hospital

    NOT_YET_RECRUITING

    Nanjing, Jiangsu, China

  • Jinhua Municipal Central Hospital

    RECRUITING

    Jinhua, Zhejiang, China

  • Nanjing Drum Tower Hospital

    RECRUITING

    Nanjing, Jiangsu, China

  • Ningbo No.2 Hospital

    RECRUITING

    Ningbo, Zhejiang, China

  • Peking Union Medical College Hospital

    RECRUITING

    Beijing, Beijing Municipality, 100000, China

  • People's Hospital of Hunan Province

    RECRUITING

    Changsha, Hunan, China

  • Ruijin Hospital Affiliated of The Shanghai Jiao Tong University Medical School

    RECRUITING

    Shanghai, Shanghai Municipality, China

  • Second Affiliated Hospital Zhejiang University College of Medicine

    RECRUITING

    Hangzhou, Zhejiang, 310999, China

  • Shandong Cancer Hospital

    RECRUITING

    Jinan, Shandong, 250117, China

  • Sir Run Run Shaw Hospital, Zhejiang University School of medicien

    RECRUITING

    Hangzhou, Zhejiang, China

  • The Affiliated Hospital of Qingdao University

    RECRUITING

    Qingdao, Shandong, 266003, China

  • The Cancer Hospital Affiliated of The Xingjiang University Medical School

    RECRUITING

    Xinjiang, Xinjiang, China

  • The First Affiliated Hospital of Xiamen University

    NOT_YET_RECRUITING

    Xiamen, Fujian, China

  • The Second Affiliated Hospital of Nanchang University

    RECRUITING

    Nanchang, Jiangxi, China

  • The Sixth Affiliated Hospital of Sun Yat-sen University

    RECRUITING

    Guangzhou, Guangdong, 510655, China

  • The first affiliated hospital of xi'an jiaotong university

    RECRUITING

    Xi’an, Shanxi, 710000, China

  • Union Hospital, Tongji Medical College, Huazhong University of Science and Technolog

    RECRUITING

    Wuhan, Hubei, China

  • West China Hospital of Sichuang University

    RECRUITING

    Chengdu, Sichuan, China

  • Yunnan Cancer Hospital

    RECRUITING

    Kunming, Yunnan, China

  • Zhejiang Cancer Hospital

    NOT_YET_RECRUITING

    Hangzhou, Zhejiang, China

  • the First Affiliated Hospital of Bengbu Medical Collage

    RECRUITING

    Bengbu, Anhui, China

  • the First Affiliated Hospital of Chongqing Medical Collage

    RECRUITING

    Chongqing, Chongqing Municipality, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.