Xuanwu Hospital, Beijing

This study looks at whether giving a clot-busting drug called Tenecteplase to stroke patients at a local hospital, before they are transferred to a specialized center for a procedure to remove the clot, can improve their recovery. The trial involves 572 adults with a specific typ…

This study looks at whether a structured rehabilitation program can delay or reduce the chance of spine degeneration near the surgery site in frail adults aged 75 and older. About 212 participants will be randomly assigned to either the rehab program or standard care and followed…

This study tests whether adding near-infrared light therapy to the drug lecanemab can safely improve thinking and memory in people with mild Alzheimer's disease. About 20 adults aged 50–90 will receive either real light therapy or a sham device along with lecanemab for 16 weeks, …

This study tests whether a special high-fat, low-carbohydrate diet (ketogenic diet) can help stop prolonged seizures in patients who do not respond to standard medications. About 84 adults aged 14-80 in the ICU will receive the diet alongside usual care. The goal is to see if the…

This study tests whether early skull surgery (decompressive hemicraniectomy) can prevent dangerous brain swelling in people who had a severe stroke and already had a clot removal procedure. About 380 participants aged 18-75 with large strokes and high risk of swelling will be ran…

This study looks at whether giving a clot-busting drug (tenecteplase) before transferring a patient to a specialized stroke center can improve recovery for people with a severe type of stroke caused by a blockage in the basilar artery. The trial involves 316 adults who had a stro…

This study tests whether adding a drug called batroxobin to standard blood thinners helps clear blood clots in the brain more quickly for people with cerebral venous thrombosis (a rare stroke). About 72 adults with acute CVT will receive either standard anticoagulation alone or c…

This study tests whether exosomes (tiny particles) from stem cells can help people who recently had a stroke. About 29 adults aged 18-70 will receive either the exosomes or a placebo through an IV. The main goal is to check safety, but researchers will also see if it improves rec…

This study tests a treatment made from stem cell exosomes (tiny particles) for people with mild to moderate Alzheimer's disease. The goal is to see if it is safe and if it can slow down memory and thinking problems. About 33 adults aged 50 and older will take part. The treatment …

This study tests whether using a balloon guide catheter that temporarily stops blood flow helps doctors remove clots more effectively in people having a stroke caused by a blocked carotid artery. About 364 adults will be randomly assigned to receive either the balloon catheter or…

This study tests the drug everolimus in 10 adults with abnormal blood vessel growths (vascular malformations). The goal is to see if the drug can shrink these growths and lower the risk of bleeding. Participants will take the drug by mouth and have regular MRI scans to check prog…

This study tests whether a gentle, early surgery using a thin tube (catheter) to drain a brain bleed, along with clot-busting medicine, helps people recover better than standard medical care alone. About 750 adults with a large brain bleed will be randomly assigned to one of the …

This study tests whether a newer clot-busting drug (tenecteplase) works better than the standard drug (alteplase) when given before a mechanical procedure to remove a large blood clot from the brain. About 850 adults who have had a severe stroke within the last 4.5 hours will be …

This study tests whether a detailed CT scan (multimodal CT) can more accurately identify the blocked artery in people having a stroke caused by a medium-sized vessel blockage. Researchers will compare the accuracy of this advanced scan against standard CT scans. The goal is to he…

This study aims to improve early detection of Alzheimer's disease in adults aged 50 and older who live in the community and have no known memory problems. Participants will first complete quick digital tests on a device to check thinking skills and dementia risk. Those with signs…

This study aims to develop a blood test to diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from about 458 participants, including healthy controls a…

This early-phase study tests whether everolimus, a drug that targets the mTOR pathway, can safely reduce seizures when added to standard treatment for adults with focal refractory epilepsy. Five participants aged 18-60 will take everolimus only during seizure events and be monito…

This study tests if a gentle ultrasound pulse to a specific brain area can improve thinking and memory in people with long COVID brain fog. 40 participants who have had brain fog for at least 4 weeks after COVID will receive either real or fake ultrasound. The goal is to see if t…

This study tests whether a common painkiller (oxycodone with acetaminophen) can safely ease moderate to severe chronic pain in people with Alzheimer's disease. Ten participants will take the medication daily for 12 weeks, and researchers will monitor pain levels, quality of life,…

This study compares two pain medicines, oliceridine and sufentanil, given through a patient-controlled pump after brain surgery. The goal is to see if oliceridine causes less nausea, a common side effect of opioids. About 174 adults having surgery in the back of the skull will ta…

This early-stage study tests whether tiny particles from stem cells, injected into the spinal fluid, can safely help people with syringomyelia whose symptoms persist after surgery or observation. 18 adults aged 18-70 will receive a single dose to check for side effects and any im…

This study tests a 6-week prehabilitation program for adults aged 75 and older who are scheduled for spine surgery. The program includes exercise, nutrition advice, health optimization, and brain exercises. Researchers want to see if it helps patients stay independent in daily ac…

This study tests a non-invasive brain stimulation method called hi-tACS to see if it can improve sleep in people with neuroimmune diseases like multiple sclerosis (MS) who also have insomnia. Researchers will measure sleep quality using questionnaires before and after treatment. …

This early-stage study tests whether galcanezumab, a drug used for migraines, can help people with mild-to-moderate Alzheimer's disease. Ten participants will receive injections over 24 weeks, and researchers will measure changes in brain proteins and thinking skills. The goal is…

This study is for people with severely narrowed arteries in the head or neck who have already had a mini-stroke or stroke. Researchers will use a special PET/MR scanner to measure blood flow and sugar use in the brain. The goal is to find better ways to diagnose and treat these p…

This study follows 500 adults who had surgery for a brain hemorrhage to see how different surgical methods affect their recovery and quality of life. Participants are aged 18 to 80 and must have had a certain type of brain bleed. The goal is to learn which treatments lead to the …

This study tracks 10,000 patients who had a bleeding aneurysm to learn more about a complication called delayed ischemic neurological deficit (DIND), which can cause lasting brain damage. Researchers will collect data on how doctors diagnose and treat DIND, and compare outcomes l…

This study is testing a new, noninvasive MRI technique to see if it can better predict stroke risk in people with narrowed arteries in the brain (ICAS). Researchers will measure blood flow pressure using a special MRI scan and follow 400 participants for one year to see who has a…

This study looks at whether giving a clot-busting drug to stroke patients 4.5 to 24 hours after symptoms start can help them recover better. Researchers will review medical records from 2,600 adults to see how many achieve good function or minimal disability. The goal is to find …