Vanderbilt University

This study looks at whether adding the medication insulin detemir to a low-calorie diet helps people with type 2 diabetes and obesity lose more weight. It also checks how the drug affects brain areas linked to food pleasure and mood. About 240 adults aged 31-60 will be split into…

This study tests whether a gentle electrical current applied to the skin of the ear can calm the nerve that controls heart rate in people with Postural Orthostatic Tachycardia Syndrome (POTS). POTS causes a racing heart and dizziness when standing. The trial involves 18 participa…

This study compares blood samples from 212 people with and without Postural Orthostatic Tachycardia Syndrome (POTS) to see if those with POTS have higher levels of certain antibodies. Researchers also want to know if these antibodies are more common in people whose POTS started a…

This study interviews and surveys 70 adolescents and adults with sickle cell disease to understand why they sometimes miss their daily medications. Researchers also ask what kind of text message reminders patients would find helpful. The goal is to learn about barriers like cost,…

This study screens people with suspected Postural Tachycardia Syndrome (POTS) and healthy volunteers to see how their bodies handle sodium and the hormone aldosterone. Participants undergo autonomic function tests and blood volume measurements. The goal is to understand if a high…

This study looks at how the kidneys handle salt in people with Postural Orthostatic Tachycardia Syndrome (POTS) compared to healthy volunteers. Researchers will give a liter of salt water through an IV and measure how much sodium comes out in urine. The goal is to understand if s…

This study looks at why over half of ICU patients develop severe muscle weakness that can last for months or years. Researchers will use muscle biopsies, ultrasound, and strength tests on 50 critically ill adults to find better ways to diagnose and track this condition. The goal …

This study looks at how the body's automatic nervous system controls blood flow in abdominal veins and how that might lead to high blood pressure in people with Multiple System Atrophy (MSA). Researchers will measure vein responses in about 16 participants aged 40-80 who have MSA…

This study looks at liver tissue from 45 adults with nonalcoholic fatty liver disease (NAFLD) to identify which fats and proteins are present and how they change as the disease gets worse. Participants are 18–65 years old and scheduled for abdominal or bariatric surgery. The goal…

This study looks at whether a special fraction teaching program helps 4th-grade students, including those with math learning difficulties, improve their fraction skills. About 2,210 students will take part, with some teachers using the program and others teaching normally. The go…

This study looks at how the body processes prostaglandins, which are natural chemicals involved in inflammation. Researchers want to see if one prostaglandin (PGD2) can be turned into another substance (11-dehydro-TxB2) through a new, unknown pathway. Ten healthy adults who are n…

This study looks at whether adding special blood tests (biomarkers) to the usual heart-lung exam can help doctors pick the right therapy for people with pulmonary hypertension. About 100 adults undergoing a routine heart catheterization will have extra blood samples taken from th…

This study is collecting DNA, brain scans, and other biological samples from 2,000 people with major depression, bipolar disorder, or psychotic disorders, as well as healthy volunteers. The goal is to better understand the physical and genetic factors behind these conditions, whi…

This study is a registry that collects information and blood samples from over 2,400 people with atrial fibrillation who are scheduled for a heart procedure called ablation. The goal is to learn which patients benefit most from the procedure and to better understand what causes a…