Could antibodies be the key to understanding POTS?
NCT ID NCT02196376
First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 28 times
Summary
This study compares blood samples from 212 people with and without Postural Orthostatic Tachycardia Syndrome (POTS) to see if those with POTS have higher levels of certain antibodies. Researchers also want to know if these antibodies are more common in people whose POTS started after a viral infection. Participants will have a medical history, physical exam, and blood draw. The goal is to better understand what causes POTS, not to test a new treatment.
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Vanderbilt University Medical Center
Nashville, Tennessee, 37232, United States
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
What this could lead to
If successful, this study could help explain what causes POTS in some people, possibly pointing toward new ways to diagnose or treat it.
What could go wrong
This is an early, observational study—it is not testing a treatment. It may not find clear differences between groups, and results may not lead to any direct medical changes.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.