University Of Maryland, Baltimore

This large phase 3 trial is testing a typhoid conjugate vaccine (Vi-TCV) in 30,000 healthy children aged 9 months to 12 years in Malawi. Half get the typhoid vaccine, half get a meningitis vaccine for comparison. The goal is to see if the typhoid vaccine prevents blood-confirmed …

This study tests a new vaccine designed to protect against three common types of Salmonella bacteria that cause serious infections in Sub-Saharan Africa. The trial includes healthy participants ranging from adults down to young infants, and compares the vaccine to a placebo to se…

This early-phase trial is testing a new type of immunotherapy called tri-specific CAR T-cells that target three proteins (CD19, CD20, CD22) on cancer cells. It is for adults with B-cell lymphomas that have come back or not responded to standard treatments. The study will enroll 1…

This early-stage trial tests the safety of combining precise radiation (SBRT) with immunotherapy (durvalumab) and two chemotherapy drugs (platinum and etoposide) for people with extensive-stage small cell lung cancer that has stopped responding to platinum chemo. The study aims t…

This study tests whether gently cooling the body (to 34-35°C) combined with muscle-paralyzing drugs can help people with severe lung injury (ARDS) recover. About 340 adults on ventilators will be randomly assigned to cooling plus paralytics or usual care. The main goal is to see …

This pilot trial tests whether training with a portable robotic ankle exoskeleton, called AMBLE, can improve ankle push-off and walking speed in adults with chronic stroke and ankle weakness. Participants will complete 30 walking training sessions over 8 to 9 weeks while wearing …

This study tests whether Ostene, a water-soluble material that plugs bleeding bone, reduces blood loss during thoracolumbar spine fusion surgery. Researchers will measure bleeding severity during surgery using a validated scale and compare results with similar past patients who d…

This study is testing a combination of two chemotherapy drugs (gemcitabine and nab-paclitaxel) with a precise type of radiation called proton therapy for people with locally advanced pancreatic cancer that cannot be removed by surgery. The goal is to find the highest safe dose of…

This pilot study is testing a two-step treatment for people whose gliomas (a type of brain tumor) have come back after standard therapy. First, doctors use a laser guided by MRI to destroy as much tumor as possible. Then, they give a short course of focused radiation. The main go…

This study tests a digital health system that reminds people with inflammatory bowel disease (IBD) to take their medication and lets them report symptoms. About 123 adults starting a new oral or injectable treatment will use the system or get standard care for 12 months. The goal…

This trial tests whether giving radiation to a smaller area of the neck can prevent throat cancer from returning while reducing side effects. People with p16-positive oropharynx cancer (a type linked to HPV) who are getting radiation therapy may be eligible. The goal is to see if…

This trial tests whether giving naloxone — the opioid-overdose reversal drug — just before buprenorphine can help people who use fentanyl start addiction treatment more quickly and with less discomfort. The study enrolls a small group of adults with opioid use disorder who test p…

This study tests whether a prebiotic supplement (Prebiotin®) can reduce inflammation and improve thinking in people with schizophrenia or schizoaffective disorder. Sixty adults aged 18-60 who are stable on antipsychotics will take the prebiotic or a placebo for 12 weeks. Research…

This study tests whether starting physical therapy, electric muscle stimulation, and high-protein supplements early in the ICU can prevent the muscle loss, weakness, and mental decline known as post-intensive care syndrome (PICS). The trial enrolls adults aged 45 and older who ar…

This phase 2 trial tests whether adding galeterone to standard chemotherapy (gemcitabine) can shrink tumors or slow disease in people with advanced pancreatic cancer that has not responded to prior treatments. The study enrolls about 15 adults with metastatic disease who have alr…

This study tests a mobile app called HealthMPowerment (HMP) designed to help young gay and bisexual men (ages 15-24) either start HIV prevention (PrEP) or stay on HIV treatment. About 1500 participants will get the app right away or after a delay. Researchers will see if the app …

This early-phase trial tests whether giving higher doses of radiation to the prostate in fewer sessions (while also treating pelvic lymph nodes) is safe for men with intermediate- to high-risk prostate cancer. The study enrolls 18 adults and uses proton beam therapy delivered fou…

This study looks at men whose prostate cancer has come back in a few spots (oligometastatic) and who have certain gene mutations. It compares standard care (hormone therapy plus radiation) against the same treatment plus a 6-month course of two drugs (niraparib and abiraterone wi…

This study tests whether having more frequent checkups with an obstetric provider or a study nurse during the first year after childbirth can help women with high blood pressure or diabetes manage their health better. One hundred women with Medicaid insurance who had these condit…

This early-phase trial tests a drug called CRD3874-SI, which activates the STING protein to help the immune system attack cancer cells. It is for adults with acute myeloid leukemia that has come back or not responded to treatment. The main goals are to check safety and find the r…

This study tests a telehealth system called Medherent for people with serious mental illness living in the community. The system dispenses medication, monitors health data like blood pressure and blood sugar, and allows virtual doctor visits. Researchers will track whether this a…

This phase 2 trial tests whether adding bavituximab to pembrolizumab can help people with advanced head and neck cancer whose tumors have stopped responding to standard immunotherapy. The study enrolled 7 participants and measures how many tumors shrink or disappear. The goal is …

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve and placing a material on it) and an indirect pulp cap (leaving some decay and sealing …

This study tests a program to help people living with HIV in Botswana stop smoking. It combines counseling with a medication called varenicline. The goal is to see if this approach helps them quit and improves their health. The study involves 750 participants who are daily smoker…

This study is testing whether a wearable heart monitor (Zio patch) worn for two weeks can detect undiagnosed atrial fibrillation in women aged 70 and older. Atrial fibrillation is a common heart rhythm problem that raises stroke risk, especially in older women. The goal is to see…

This study tests whether giving the antibiotic azithromycin to pregnant women and their babies during routine care can prevent stillbirths and infant deaths in Mali, a country with very high infant mortality. Over 99,000 participants are involved in this large, placebo-controlled…

This study tests whether taking oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in people aged 65 and older. Participants are randomly assigned to receive either vancomycin or standard care. The goal is to see if the drug reduc…

This study tests a personalized support program (C4) to help Black men who have sex with men take their HIV prevention medication (PrEP) consistently. About 350 men will either get the program or standard care. The program addresses personal needs like mental health and housing t…

Researchers are testing whether semaglutide, a drug used for diabetes and weight loss, is safe and tolerable in adults with cocaine use disorder. The trial includes 40 people who use cocaine often, some of whom also have HIV. Participants receive weekly injections of semaglutide …

This study tests a program called FPCI-AL that helps staff in assisted living communities interact more positively with residents who have dementia. Researchers will work with staff for several months to improve care interactions. The goal is to reduce residents' behavioral sympt…

This early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…

This study is testing whether a moderate exercise program can improve strength, balance, and endurance in children with sickle cell disease. Twenty children ages 6 to 17 will take part in strengthening and endurance exercises. Researchers will measure changes in muscle strength, …

This study tests whether chewing sugar-free gum during bowel preparation for colonoscopy can reduce discomfort and improve satisfaction. About 100 adults aged 45-75 will chew gum before and after their prep solution. The goal is to see if this simple trick helps more people compl…

This study explores whether immersive virtual reality can help reduce chronic pain in people with temporomandibular disorder (TMD). About 259 participants will experience active VR, a sham VR, or no VR while their pain tolerance is measured. The goal is to understand how VR works…

This study tests whether eating only within a 10-hour window each day can help prevent frailty in people over 55 who are on hormone therapy for prostate cancer. Frailty makes it harder to recover from stress and can lead to loss of independence. The trial will enroll 30 participa…

This study tests whether a ketogenic diet—low in carbs, high in fat—can reduce symptoms in people with schizophrenia or schizoaffective disorder. Fifty adults will be randomly assigned to either the ketogenic diet or a regular diet for several weeks. Researchers will measure chan…

This study aims to create a whole blood substitute by combining artificial oxygen carriers, plasma, and platelets. Researchers will test these mixtures in the lab using blood from 250 healthy volunteers to see if they can match the performance of real blood. The goal is to have a…

This study looks at how red blood cells break down during prolonged heart-lung bypass in cardiac surgery, releasing free hemoglobin into the blood. Researchers will measure these levels and related proteins in adults undergoing complex heart procedures to see if they can predict …

This study asks how long a spinal cord stimulator (SCS) trial should last to accurately predict whether it will relieve chronic pain. People with chronic pain undergoing a standard SCS trial will fill out daily surveys about their pain and function. The goal is to find the shorte…

This study follows people with chronic hepatitis B or C for up to 10 years to track how the disease changes over time. A smaller group with hepatitis B will receive the drug tenofovir alafenamide for 2 years to see if it reduces liver stiffness. Participants provide blood samples…

This study tests if a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer common illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengthe…

This study aimed to see if a personalized exercise app (Gingko Active) could improve physical function in adults aged 45 and older better than a standard exercise booklet. The trial was withdrawn before any participants enrolled, so no results are available. The app was designed …

This study teaches clinicians and researchers how to start and follow a medical ketogenic diet to improve mental health. Participants first attend a mastery class, then optionally try the diet themselves for 4 weeks with group support. The goal is to help professionals feel confi…

This study looks at whether a single dose of diclofenac, a common pain reliever, can change a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-blind fashion.…

This study was designed to see if a new method for fitting breast pump flanges (the part that goes over the breast) helps parents of babies in the NICU produce more milk and feel more satisfied with pumping. Researchers planned to compare the new fitting method to standard instru…

This study tests whether a drug can help red blood cells work better in low-oxygen (hypoxia) and cold (hypothermia) conditions, which are common in high-altitude or military environments. Researchers will measure how the drug affects red blood cell energy and antioxidant defenses…

This study looks at two common surgeries for a certain type of hip fracture in people aged 60 and older: hip replacement or using screws/pins to hold the bone together. The main goal is to see if a larger study is possible by checking how many people join, how well the treatments…

This study aimed to find the best length of time for patients to take antibiotics after surgery for an infected joint replacement. It planned to compare different antibiotic durations to see which works best to prevent the infection from coming back and to avoid antibiotic resist…

This study looks at the small tooth-colored bumps (attachments) used with Invisalign aligners to help move teeth. Researchers want to see which design—optimized or conventional—is placed more accurately and holds its shape longer. Thirty adults starting Invisalign treatment will …

This study looks at whether patients with surgically treated leg, pelvis, or hip socket fractures can safely start walking right away instead of waiting 6-12 weeks. About 100 adults will be randomly assigned to immediate weightbearing or delayed weightbearing. The goal is to see …

This observational study at the University of Maryland will follow 40 pregnant women to see how their physical activity levels influence the development and function of the placenta. Participants will provide biological samples and health information during pregnancy and at deliv…

This study looks at how the typhoid vaccine changes the immune system and bacteria in the gut. About 87 healthy adults getting a routine colonoscopy will either receive the vaccine before the procedure, after, or not at all. Researchers will analyze blood, tissue, and stool sampl…

This study looks at whether a person's genes can predict how their body responds to canagliflozin, a drug used for type 2 diabetes. About 700 healthy Amish adults will take the drug for five days, and researchers will measure changes in urine sugar and other markers. The goal is …

This study aimed to compare two devices—ultrasound and a near-infrared device called Vein Viewer—to see which helps emergency room staff start IVs faster in patients with difficult veins. The goal was to reduce delays in care. However, the study was withdrawn before enrolling any…

This early-stage study planned to test whether a drug called glucagon-like peptide-1 (GLP-1) could protect blood vessels from damage caused by repeated low blood sugar in people with type 1 diabetes. The researchers aimed to enroll 40 adults aged 18–50. However, the study was wit…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to learn if a natural gut hormone called GLP-1 can change these effects. The study involves 28 participants and measures change…