University Of Iowa

This study tests whether psilocybin or ketamine, given alongside therapy, can help people with moderate to severe alcohol use disorder drink less. Eighty adults who have at least 4 heavy drinking days per month will receive either psilocybin or ketamine in a double-blind setup. R…

This study tests whether an oral antibiotic (doxycycline) can help people with wet age-related macular degeneration (AMD) who still have fluid in their eye despite standard injections. About 50 participants will receive either doxycycline or a placebo for several months. The goal…

This study looks at whether a 6-week computer-based brain training program can help adults aged 40-65 stay physically active. Participants will also do home-based aerobic exercise with coach support. The goal is to see if improving thinking skills makes it easier to keep up an ex…

This study looks at how changing the heel height in carbon fiber leg braces affects foot pressure, pain, and comfort during walking. Twenty adults with traumatic hindfoot injuries who have pain when standing will test different braces. The goal is to find the best brace design to…

This study tests whether custom carbon fiber foot braces can lower the force on the front of the foot in people recovering from leg injuries. About 60 adults will wear the braces and get special training, with some using a visual feedback system to see their foot pressure. The go…

This early-stage study is testing whether a specific type of nerve block (TLIP block) can help older adults (65+) recover better after spinal fusion surgery. The blocks are given before surgery to reduce pain, opioid use, and confusion (delirium) after the operation. The main goa…

This study looks at two common methods of giving extra pain medicine (opioids) to people recovering from open abdominal surgery. Participants will already have an epidural for local anesthetic. The researchers want to see if adding opioids to the epidural works as well as giving …

This study looks at whether inflammation from e-cigarette use harms blood vessel function in young adults aged 18-24. Researchers will compare vapers and non-vapers, measuring blood vessel responses after giving an anti-inflammatory drug or placebo. The goal is to understand if i…

This study aims to understand why some people with epilepsy die suddenly (SUDEP). Researchers will monitor how seizures affect breathing, heart function, and the ability to wake up. They will test how well the body senses carbon dioxide levels. About 335 adults with epilepsy will…

This study aims to find new genes that cause Charcot-Marie-Tooth disease (CMT) and identify genetic modifiers that explain why symptoms vary among people with the same genetic change. Researchers will enroll up to 1,050 participants, including those with a known PMP22 duplication…

This study looks at how stressful childhood experiences may harm blood vessel function in young adults aged 18-29. Researchers will test if reducing cell stress can improve blood vessel health and response to stress. The goal is to find ways to lower heart disease risk in people …

This study looks at whether people who carry one copy of the cystic fibrosis gene (called CF carriers) are more likely to get dehydrated or have heat-related problems. Researchers will compare 100 CF carriers with 100 non-carriers using surveys and a 45-minute sauna session. The …

This study aims to see if special force sensors can reliably measure how tight a carbon-fiber leg brace (ankle-foot orthosis) presses against the leg. Researchers will test 60 people: healthy volunteers, regular brace users without nerve damage, and regular brace users with perip…

This study looks at how changing the heel height and stiffness of an ankle-foot brace (AFO) affects walking in people who use one daily. About 40 adults with leg injuries or nerve problems will walk with different heel cushions while researchers measure motion, comfort, and pain.…