Brain training boosts exercise habits in midlife to fight Alzheimer's
NCT ID NCT06338774
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study looks at whether computer-based brain exercises can help adults aged 40-65 stay physically active. Participants will do cognitive training and aerobic exercise at home with coach support. The goal is to see if improving thinking skills makes it easier to keep up an exercise routine, which may lower Alzheimer's risk.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 264 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Sep 2024
- Expected to finish
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Nov 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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40 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Between the ages of 40 and 65 years old * Full-time working status of an average of 35 hrs./week or more * Scoring as "Low Active" by the short form of the International Physical Activity Questionnaire (IPAQ) * Eligible to participate in an aerobic exercise intervention based on the Physical Activity Readiness Questionnaire * Approval from their Primary Care Physician for approval to participate in the prescribed training program * Corrected vision of 20/40 * Fluent in English to ensure instructions for cognitive assessments and training are understood clearly Exclusion Criteria: * Impairments in hearing inhibiting the ability to discuss study instructions or directions * Visual impairments that prevent the perception of color, or loss of sight in the visual field * Qualify as "high risk" for exercise-induced adverse events by American College of Sports Medicine criteria will be excluded, which includes known or symptomatic chronic cardiovascular or metabolic disease * Not fluent in English * Inability to comply with experimental instructions or access a tablet or computer to complete computerized training * Previous diagnosis of a neurological or psychiatric condition, including diagnosis with any of the following: major depression, Attention Deficit Disorder or attention-deficit/hyperactivity disorder (ADHD), schizophrenia or bipolar disorder, multiple sclerosis, epilepsy, meningitis, Parkinson's disease, stroke, Transient Ischemic Attack (TIA), or brain aneurysm surgery. * Previous diagnosis of a heart condition, cardiovascular disease, or a recent cardiovascular event (such as high blood pressure or cholesterol) that would increase the risk for an adverse event in response to vigorous exercise, Chronic obstructive pulmonary disease (COPD), uncontrolled asthma (this includes anyone who has asthma but is not on medication. * Previous diagnosis of a chronic condition such as cystic fibrosis, unregulated thyroid disorder (this includes anyone with thyroid disease that is not on medication), untreated diabetes, renal or liver disease, heart murmur, arrhythmia, or irregular heartbeat. * Previous brain surgery or injury associated with concussion or loss of consciousness that required rehabilitation or caregiver assistance to regain function (i.e., dressing/personal hygiene) * Previous diagnosis of Alzheimer\'s or related dementias * Current or previous cancer treatments within the last 6 months * Pregnant or trying to get pregnant
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
2 sites. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Center for Cognitive and Brain Health
RECRUITINGBoston, Massachusetts, 02115, United States
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Psychological and Brain Sciences Building
RECRUITINGIowa City, Iowa, 52242, United States
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Other studies related to the condition(s) this trial covers.
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