University Of Iowa

This early-stage study tests whether adding high-dose vitamin C to a standard chemotherapy drug (gemcitabine) can help control advanced soft tissue or bone sarcomas that cannot be removed by surgery or have spread. About 30 adults will receive the combination intravenously. The m…

This study looks at whether talking to a pharmacist over the phone can help smokers quit. About 80 people who are current smokers and in a lung cancer screening program will take part. Some will get regular phone calls from a pharmacist for 12 weeks, while others will just fill o…

This study tests whether an 8-week very low-calorie diet (800-960 calories per day) can reduce liver fat and scarring in 20 adults with obesity and non-alcoholic fatty liver disease (NAFLD). Participants are randomly assigned to the diet or a lower-calorie control group. The goal…

This study compares two treatments—casting and bracing—for young children (up to age 3) with idiopathic early-onset scoliosis, a condition where the spine curves. The goal is to see which method better slows curve progression or corrects it, while also tracking quality of life. A…

This study tests whether a special video program for pregnant women can help prevent early childhood cavities in their babies. Researchers will enroll 1,268 pregnant women from the WIC program and follow them until their child is 3 years old. The program uses motivational videos …

This early study looks at whether a 10-week exercise program done at home can improve physical fitness in women who have finished treatment for endometrial cancer. Ten participants will do exercises like chair stands and arm curls, guided by remote coaching. The goal is to see if…

This study looks at whether fish oil, alone or with the drug salsalate, can improve blood markers linked to nerve health in people with type 2 diabetes and diabetic neuropathy (nerve pain). About 100 adults will take fish oil capsules for 4 months, then add salsalate tablets for …

This study tests a new device called a cystoelastometer that connects to a standard urinary catheter to measure bladder pressure at home. Researchers want to see if patients and caregivers can use it easily and accurately. The study involves 30 people with neurogenic bladder who …

This study in 24 healthy adults compares how much metronidazole enters the blood when applied as a gel or cream on skin treated with a micropatch. The goal is to see which formulation works better for delivering the drug through the skin. Participants will have blood samples and …

This study follows over 2500 adults with neuroendocrine tumors (NETs) to learn how symptoms affect their lives and how doctors choose treatments. Participants fill out surveys about quality of life and care experiences over 18 months. The goal is to find the best ways to sequence…

This study looks at whether a common toothpaste-like product called MI Paste can change the types of bacteria and fungus living in the mouths of people aged 65 and older who wear a full upper denture. Researchers will also check if the paste makes dentures feel more comfortable a…

This study was designed to see if custom carbon fiber braces can reduce pressure on the ankle joint after a fracture, potentially lowering the risk of arthritis. Researchers planned to test the braces in adults aged 18-65 with healed ankle fractures. The study was withdrawn befor…

This study looks at how the brain grows and changes in children and young adults with Juvenile-onset Huntington's disease (JoHD). Researchers will use MRI scans, thinking tests, and behavior checklists to compare brain development in JoHD versus adult-onset Huntington's. The goal…

This study looks at very small premature babies (weighing 2.2 pounds or less) to understand why some develop low blood pressure in their first week of life. Researchers will monitor heart and lung changes in babies with and without low blood pressure. The goal is to learn more ab…