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Epidural or IV? study seeks best way to deliver opioids after surgery

NCT ID NCT06559969

Symptom relief Sponsor: University of Iowa Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at two common methods of giving extra opioids (strong painkillers) to patients recovering from open abdominal surgery who already have an epidural. Researchers want to see if adding opioids to the epidural fluid works as well as giving them through an IV, and whether one method causes fewer side effects. About 80 adults aged 18 to 85 will take part.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2/3

Runs two stages together: whether the treatment works, then large-scale confirmation.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Sep 2024

Expected to finish

Mar 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 85 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age including and between 18 to 85 years old 2. Planned open abdominal procedure with an incision that is or includes above the umbilicus, where epidural would normally be offered and epidural would be maintained for an average of 4 to 5 days 3. Patient has consented for an epidural 4. Patient is able to converse in English 5. Patient is able to use a patient controlled pump Exclusion Criteria: 1. Has a known contraindication for an epidural 2. Known mental or cognitive disability 3. History of chronic opioid use or substance abuse disorder 4. Pre-operative use of opioids 5. History of chronic pain 6. Routine use of marijuana 7. Incarcerated 8. Unable to converse in English 9. Planned to remain intubated post-operatively 10. Need for post-operative use of anticoagulant regiment that would be contraindicated with an indwelling epidural catheter 11. End stage renal disease or dialysis 12. Hepatic disease that affects metabolism of drugs 13. Known contraindication to any of the study drugs 14. Known pregnancy or positive pre-operative pregnancy test 15. Known neurological condition that may affect motor or sensory systems

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Conditions

The condition(s) this trial relates to.

agnosia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Laparotomy

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • University of Iowa Health Care

    RECRUITING

    Iowa City, Iowa, 52242, United States

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