University Of Cincinnati

This study compares two types of metal plates used to fix a broken hip socket (acetabular fracture). 60 adults under 65 will be randomly assigned to receive either a rim plate or a buttress plate during surgery. The goal is to see which method leads to better bone healing, less j…

This study is for people whose head and neck cancer has come back after previous radiation. It tests whether giving a type of immunotherapy (pembrolizumab) along with either standard or proton radiation before surgery is safe and works better than surgery alone. About 40 adults w…

This study looks at whether a procedure called endovascular thrombectomy (EVT) can help people who have a stroke but already had a moderate-to-severe disability before the stroke. About 1,060 adults with a large blood vessel blockage in the brain will be randomly assigned to get …

This study tests a new medicine called AM3101 to see if it helps meniscus tears in the knee heal better after surgery. About 74 people aged 18 to 40 with a torn meniscus will get either AM3101 or a placebo injection during their repair surgery. The goal is to improve healing and …

This study tests whether using a brain wave monitor to guide a step-by-step treatment plan can reduce harmful electrical events after severe traumatic brain injury. About 72 adults who need emergency brain surgery will be randomly assigned to standard care or the monitor-guided a…

This study tests a new device called VirtuaCare™ that guides patients through at-home exercises after shoulder surgery and gives real-time feedback on their form. The goal is to see if it helps people stick to their prescribed therapy better than standard care. About 60 adults wh…

This study looks at whether a supplement called N-acetylcysteine (NAC) and mindfulness-based therapy can help young people aged 15 to 24 with mild depression. Researchers will measure changes in brain chemicals and connections linked to mood and attention. The goal is to find bet…

This study tests whether a tongue endurance exercise program can improve swallowing in adults who have trouble swallowing after a stroke. About 70 people will be randomly assigned to do either the tongue exercises or a sham therapy at home for 8 weeks. Researchers will measure ch…

This study is testing whether starting pelvic floor physical therapy soon after radiation treatment can reduce bowel and bladder problems in women with cervical cancer. Twenty-eight women who are getting radiation to the pelvis will begin therapy four weeks after their radiation …

This study looks at whether moderate or high-intensity walking exercise is better for improving walking in people who had a stroke at least 6 months ago. About 156 participants will be randomly assigned to one of two exercise programs, each done with a physical therapist for 45 m…

This study tests a special type of radiation called lattice therapy for people with large, hard-to-treat tumors. The goal is to see if it can shrink tumors better and with fewer side effects than standard radiation. About 37 adults with advanced solid tumors will receive this tre…

This study tests whether a daily probiotic pill can safely reduce stomach and bowel side effects in people receiving radiation therapy for pelvic cancers like prostate, rectal, or cervical cancer. About 20 adults will take the probiotic during their radiation treatment, and resea…

This study looks at whether using a continuous passive motion (CPM) machine after surgery for certain leg fractures can lower pain and reduce the need for narcotic painkillers. About 100 adults who have had surgery for a broken hip socket, thighbone, or shinbone will be split int…

This study compares two standard pain-block methods for women having a mastectomy (breast removal) due to breast cancer or high risk. One method uses a nerve block before surgery, the other during surgery. The goal is to see which approach reduces the need for opioid painkillers …

This study compares two forms of DHA (a type of omega-3 fat) in 153 older adults aged 55-82 who have early signs of memory decline. One group takes a special form called LPC-DHA, the other takes standard DHA, for 24 weeks. Researchers measure DHA levels in spinal fluid and blood,…

This early-phase study tests whether letrozole, a drug used for breast cancer, can get into the brain and reach tumor tissue in people with recurrent high-grade gliomas. About 39 adults will take letrozole along with standard treatments. The main goal is to measure drug levels in…

This early-phase study looks at how a natural protein called C-peptide might help people with type 1 diabetes recover faster from low blood sugar (hypoglycemia). Researchers will measure hormone levels and liver sugar production in 38 adults. The goal is to understand if C-peptid…

This study looks at how hormone levels change after a meal in people with cystic fibrosis. Researchers want to find links to blood sugar problems that often happen in this group. About 61 adults aged 18 to 45 with cystic fibrosis will take part. No treatment is given—only blood s…

This study looks at why walking is harder for people who have had a stroke. Researchers will test a new method to measure walking efficiency using motion and force, comparing it to standard energy-use tests. 18 adults with chronic stroke who walk slowly will do three short treadm…

This study explores whether mild electrical stimulation of the spine can change how the brain processes body signals, which may be disrupted in major depression. About 67 adults with depression will receive different doses of stimulation or a sham (fake) treatment to see which do…

This study is testing whether brain scans and a technique called transcranial magnetic stimulation can predict how well someone will recover arm movement after a stroke. Researchers will collect data from 657 adults who recently had a stroke and have arm weakness. The goal is to …