University Hospitals Cleveland Medical Center

This study compares two methods of closing the breastbone after open-heart surgery: rigid plate fixation and traditional wire cerclage. Researchers want to see which technique leads to better bone healing and fewer wound problems. The trial involves 250 adults at high risk for co…

This study tests a new surgery called transverse tibial bone transport for people with severe leg artery disease who have no other treatment options. The goal is to improve blood flow, heal wounds, and prevent major amputation. Ten participants will be followed to see if the proc…

This study compares two surgical options for people with large, irreparable rotator cuff tears that cannot be fully repaired. One group gets a partial repair alone, the other gets a partial repair plus an extra procedure called superior capsule reconstruction. Researchers will me…

This study compares a new DNA-based test (DNA PCR) to the standard urine culture for diagnosing urinary tract infections (UTIs) in adults. Participants with UTI symptoms will be randomly assigned to one of the two testing methods. The goal is to see if the DNA test leads to faste…

This study tests an AI tool that reads chest X-rays to find lung nodules, which can be a sign of lung cancer. About 46,000 chest X-rays will be analyzed by both the AI and radiologists to see how well the AI performs. The goal is to see if AI can help speed up and improve detecti…

This study aims to see if using a home blood pressure monitor can accurately diagnose high blood pressure in African American teenagers, a group at higher risk. Currently, diagnosis requires multiple doctor visits, which is inconvenient and can be inaccurate. Researchers will com…

This study tests a program that teaches people with epilepsy how to use rescue medication to manage repeated seizures. In the first phase, patients, caregivers, and doctors help design the program. In the second phase, about 30 adults use the program for 6 months to see if it red…

This study is testing a numbing injection (erector spinae plane block) given before lumbar spine fusion surgery. The goal is to see how well it spreads, how much area it numbs, and how effectively it reduces pain and the need for painkillers after surgery. About 32 adults aged 21…

This study tests whether adding acupuncture to standard behavioral changes (like diet and bladder training) can better relieve bladder pain in women with interstitial cystitis. About 34 women who have not had prior treatments will be split into two groups: one doing only behavior…

This study looks at whether a digital health platform called Band Connect helps people follow their home exercise program after shoulder replacement or rotator cuff repair. About 500 adults aged 18 to 89 will use the platform, and researchers will track how many exercises they co…

This study looks at whether a prediction model can help reduce unnecessary antibiotic use for urinary tract infections (UTIs) in the emergency room. About 47 women diagnosed with a UTI and sent home with antibiotics will be included. The goal is to see if the model can safely gui…

This study aims to create a large registry of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples to see how these tiny organisms differ from person to person based on factors like diet, medications, and where the…

This study uses eye-tracking technology to measure how people with bipolar disorder pay attention, respond to rewards, and control their thoughts. Researchers will compare adults with bipolar disorder who also have anxiety or substance use issues to those without these conditions…

This study looks at whether giving pregnant patients extra resources, like a 'care box,' during an emergency department visit helps them attend follow-up prenatal appointments and feel more confident about their pregnancy. About 50 participants will be randomly assigned to receiv…

This study aims to find gene markers that can predict how well a person with psoriasis will respond to certain drugs, so doctors can choose the best treatment from the start instead of trying different ones. About 56 adults with plaque psoriasis will try two FDA-approved drugs fo…

This study tests a wearable sensor that measures muscle oxygen levels in high school and college athletes recovering from ACL or hip surgery. The goal is to see if the sensor can give doctors better data to decide when it's safe for athletes to return to play. About 226 participa…

This study compares two imaging methods—CT scan and transesophageal echocardiogram (TEE)—to see which better detects problems like leaks or blood clots after a heart device (Watchman FLX) is implanted. About 320 adults will get both tests 90 days after their procedure. The goal i…

This study compares two types of replacement heart valves (self-expanding vs. balloon-expandable) in people with aortic valve stenosis. Researchers will use exercise MRI to measure how well each valve works during physical activity. The goal is to see which valve provides better …

This study explores whether microlearning—short, targeted educational lessons—can help patients remember important care instructions, feel more confident managing their recovery, and improve their overall recovery after same-day surgery. About 50 adults scheduled for specific gyn…

This study looks at two methods for recovering blood from sponges used in heart and lung surgeries: manually wringing them out versus using an FDA-approved automated suction device. Researchers will measure how much blood is recovered and how healthy the red blood cells remain. T…

This study looks at whether a 'teach-back' education method helps people who had surgery for broken bones remember important details about their injury and treatment. About 216 participants will either receive this extra education or standard care. Researchers will measure how mu…