University Hospitals Cleveland Medical Center

This study compares two ways to treat stress urinary incontinence (leaking urine when coughing or sneezing) in women who are also having surgery for pelvic organ prolapse. One group gets a standard sling (a small mesh tape), the other gets a bulking injection (a gel that thickens…

This study compares two methods for closing the breastbone after open-heart surgery: rigid plate fixation (using a metal plate and screws) versus traditional wire cerclage (using stainless steel wires). The trial will enroll 250 adults at high risk for wound complications, such a…

This pilot study tests whether milk thistle, an herbal supplement, can improve fatty liver disease in children aged 9 to 22. Twenty participants will receive either milk thistle capsules or a placebo, plus lifestyle advice. The goal is to see if milk thistle lowers liver enzymes …

This study compares two surgical options for people with large, irreparable rotator cuff tears: partial repair alone versus partial repair plus a tissue graft to rebuild the shoulder capsule. Researchers will track pain, function, and quality of life in 105 participants over two …

This study looks at whether a community health worker (CHW) can act as a diabetes technology coach for Black children with type 1 diabetes who use an automated insulin delivery system but still have high blood sugar (HbA1c of 8% or higher). Over 6 months, families meet monthly wi…

This study looks at whether eating a Mediterranean diet can improve psoriasis symptoms in people who are about to start a biologic medication (anti-IL-17 or anti-IL-23). About 36 adults with moderate to severe psoriasis will be randomly assigned to follow the diet or not. The goa…

This study compares a new DNA-based test (PCR) to the standard urine culture for diagnosing urinary tract infections (UTIs) in adults. About 136 people with UTI symptoms will be randomly assigned to one of the two tests. Researchers will track how quickly treatment starts, how sy…

This study aims to see if using a home blood pressure monitor can accurately diagnose high blood pressure in African American teenagers, who are at higher risk. Researchers will compare home readings to a 24-hour monitor, the current best method. The goal is to make diagnosis eas…

This study tests whether an AI tool can accurately detect lung nodules on chest X-rays. About 46,000 chest X-rays will be analyzed by both AI and radiologists to see how well they agree. The goal is to see if AI can help speed up and improve the detection of potentially serious l…

This study teaches people having colorectal surgery simple mindfulness exercises like deep breathing and staying focused on the present. Half the participants learn these skills before surgery and get a refresher afterward, while the other half receives standard care. The goal is…

This study looks at using a special fish skin graft (Kerecis™) during gender-affirming vaginoplasty to help the vagina heal better. About 20 transgender women will have the surgery and be followed for a year. Researchers will check healing, vaginal size, pain, quality of life, an…

This study looks at whether a numbing injection called an erector spinae plane (ESP) block can better control pain after lumbar spine fusion surgery. About 32 adults will receive the injection before surgery, and researchers will track their pain scores and how much pain medicine…

This study is testing whether a group music therapy program, called POPSINGER, is practical and well-liked by people with chronic pain. The program includes both in-person and online sessions. Researchers will track how many people stay in the study and attend sessions to see if …

This study aims to help people with epilepsy who have repeated seizures learn how to use rescue medication more effectively. In the first phase, patients, caregivers, and doctors will help design an educational program. In the second phase, about 35 adults will try the program fo…

This study looks at whether a digital platform called Band Connect helps people recovering from shoulder surgery or rotator cuff repair do their home exercises more consistently. About 500 adults aged 18 to 89 will use the platform, and researchers will track how many exercises t…

This study helps people with ongoing back pain after surgery compare two treatments: spinal cord stimulation (a device that sends electrical pulses) and a pain pump (which delivers medicine directly to the spine). Participants try both treatments temporarily and choose which one …

This study looks at whether adding acupuncture to simple behavioral changes can help women with bladder pain syndrome (interstitial cystitis) who haven't had other treatments. 34 women will either make behavioral changes alone or also receive weekly acupuncture for 6 weeks. Resea…

This study tests whether a vaginal estrogen cream can improve sexual function in breastfeeding women who are 6 weeks to 6 months postpartum. About 100 sexually active women who had a full-term birth and plan to breastfeed will use the cream or not. The goal is to see if the cream…

This study looks for gene markers that could predict how well a person with psoriasis will respond to certain FDA-approved drugs. About 56 participants will try two different psoriasis medications for 8 weeks each, while researchers take blood and skin samples. The goal is to mak…

This study is testing a wearable sensor that measures muscle oxygen levels in high school and college athletes recovering from ACL or hip surgery. The goal is to see if the sensor can give doctors and trainers better data to decide when an athlete is ready to return to sports. Ab…

This study looks at whether a blood marker called phosphatidylethanol (PEth), which reflects alcohol use over the past few weeks, can predict complications after surgery. Researchers will test PEth levels in 170 adults having elective surgery at University Hospitals Cleveland Med…

This study looks at two methods of recovering blood from surgical sponges used during heart and lung surgeries: manually wringing them by hand versus using an FDA-approved automated suction device called ProCell. Researchers will check how well each method preserves red blood cel…

This study tests a prediction model to help doctors decide if antibiotics are really needed for urinary tract infections (UTIs) in the emergency room. About 47 women with UTIs will be enrolled. The goal is to reduce unnecessary antibiotic use and fight antibiotic resistance.

This study compares two types of replacement heart valves for people with aortic stenosis (a narrowed heart valve). Researchers will use exercise MRI scans to see which valve type works better during physical activity. About 90 adults who are already scheduled for valve replaceme…

This study aims to create a detailed map of the bacteria and fungi living on the skin and in the gut of 5,000 healthy volunteers. Researchers will collect samples from different body sites and analyze how factors like diet, location, and medical history shape each person's unique…

This study uses eye-tracking technology to measure how people with bipolar disorder pay attention, respond to rewards, and control their thoughts. Researchers will compare different groups, including those with anxiety or substance use issues. The goal is to better understand the…

This study compares two imaging methods—cardiac CT and transesophageal echocardiogram (TEE)—for checking a heart device called Watchman FLX after it's placed to prevent strokes. About 320 adults will get both tests 90 days after their procedure to see which method better detects …

This study looks at whether giving extra prenatal resources, like a 'care box,' to pregnant patients in the emergency room helps them attend follow-up OBGYN appointments and feel more confident about their pregnancy. About 50 participants will be randomly assigned to receive the …

This study looks at whether a 'teach-back' education method helps people who had surgery for broken bones in their pelvis or legs remember their injury and treatment instructions. About 216 participants will either receive this extra education or not. Researchers will measure how…