Could milk thistle help kids with fatty liver disease?
NCT ID NCT06477146
First seen Feb 01, 2026 · Last updated Jun 22, 2026 · Updated 20 times
Summary
This pilot study tests whether milk thistle, an herbal supplement, can improve fatty liver disease in children aged 9 to 22. Twenty participants will receive either milk thistle capsules or a placebo, plus lifestyle advice. The goal is to see if milk thistle lowers liver enzymes and reduces liver fat, offering a simpler alternative to strict diet and exercise.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Hospitals Cleveland Medical Center
RECRUITINGCleveland, Ohio, 44106, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Milk thistle (standardized to 240 mg silymarin per 300 mg capsule)
What this could lead to
If it works, milk thistle could offer an easier-to-follow treatment option for children with fatty liver disease, potentially reducing the need for strict diet and exercise alone.
What could go wrong
This is a very small pilot study (20 participants) with no guarantee of success. Milk thistle may not improve liver health, and side effects are possible. Results may not apply to all children.
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.