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Could milk thistle help kids with fatty liver disease?

NCT ID NCT06477146

Recruiting now Disease control Sponsor: University Hospitals Cleveland Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This pilot study tests whether milk thistle, an herbal supplement, can improve fatty liver disease in children aged 9 to 22. Twenty participants will receive either milk thistle capsules or a placebo, plus lifestyle advice. The goal is to see if milk thistle lowers liver enzymes and reduces liver fat, offering a simpler alternative to strict diet and exercise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
Milk thistle (standardized to 240 mg silymarin per 300 mg capsule)
What this could lead to
If it works, milk thistle could offer an easier-to-follow treatment option for children with fatty liver disease, potentially reducing the need for strict diet and exercise alone.
What could go wrong
This is a very small pilot study (20 participants) with no guarantee of success. Milk thistle may not improve liver health, and side effects are possible. Results may not apply to all children.

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Conditions

The condition(s) this trial relates to.

fatty liver disease metabolic dysfunction-associated steatotic liver disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ALCOHOLIC FATTY LIVER DISEASE (NAFLD)

Contacts and locations

Locations

  • University Hospitals Cleveland Medical Center

    RECRUITING

    Cleveland, Ohio, 44106, United States

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