Universitätsklinikum Hamburg-eppendorf

This study tests whether raising a natural body chemical called beta-hydroxybutyrate (BHB) — through a low-carb diet or a special drink — can safely improve the effectiveness of immunotherapy in people with multiple myeloma. About 45 participants will be randomly assigned to one …

This study tests whether awake patients with acute breathing failure who lie face down (prone positioning) for at least 10 hours a day for 3 days are less likely to need a breathing tube or die within 28 days, compared to standard care. The trial will include 342 intensive care u…

This study tests a combination of two drugs, belantamab mafodotin and venetoclax, with or without dexamethasone, in people whose multiple myeloma has come back and is hard to treat. The cancer must have a specific genetic change called t(11;14). The goal is to find the safest dos…

This study tests whether starting heart rhythm control therapy soon after a stroke can prevent future strokes, heart-related deaths, or hospital stays in people with atrial fibrillation. About 1,746 participants will receive either early comprehensive treatment or usual care. The…

This study compares giving norepinephrine continuously versus as needed to prevent low blood pressure during anesthesia in high-risk non-cardiac surgery patients. About 446 adults aged 45 and older with certain risk factors will participate. The goal is to see which method better…

This study tests a new short-term talk therapy called ORPHYS for people with advanced cancer who feel deep fear, hopelessness, or loneliness. About 160 patients will be randomly assigned to receive ORPHYS or standard support. The goal is to see if ORPHYS better reduces emotional …

This study tests a new, non-invasive device that delivers gentle electrical stimulation to the brain in sync with a person's own hand tremor. The goal is to reduce shaking in people with Parkinson's disease who have moderate to severe hand tremors. Ten participants will receive t…

This study tests whether a short bout of cycling exercise right before immunotherapy (nivolumab and ipilimumab) can boost the immune system and improve treatment outcomes in people with advanced melanoma. Researchers want to see if this approach is practical and safe for patients…

This international registry collects medical data and biological samples from children and adults with rare brain tumors like medulloblastoma and ependymoma. By gathering information from patients not in clinical trials, researchers hope to improve treatment recommendations and i…

This study looks at how a stroke can disrupt the body's automatic functions, like heart rate and blood pressure control. Researchers will compare 100 people who had a stroke or a mini-stroke using brain scans, blood tests, and heart function tests. The goal is to understand why t…

This study is a registry that tracks 1000 people with a leaky mitral valve (mitral regurgitation) who are getting a new valve placed through a tube in an artery (TMVR). The goal is to see how well this procedure works in everyday medical practice and what complications might occu…

This study brings together health data from about 3 million people across 40 countries to see how common risk factors like high blood pressure, smoking, and diabetes affect heart disease and death rates. Researchers want to understand how these risks differ by region and sex. No …

This study is observing 1,000 people hospitalized with acute heart failure to learn how to better predict their outcomes. Researchers will use blood tests, imaging, and other measurements to identify different patient types. The goal is to improve future treatment and care for th…

This study tests a new interface that synchronizes two types of brain stimulation—transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS)—in people with Parkinson's disease. The goal is to see if the interface can precisely time the stimulations and m…

This study is testing a new online learning tool designed to help people with cancer improve their ability to find and understand health information on the internet. About 660 cancer patients will take part, and they will be randomly assigned to use the online tool, read a PDF wi…

This study looks at 264 adults recovering from non-cardiac surgery to see if wearing a continuous vital sign monitor (instead of nurses checking vitals at set times) reduces the time spent with dangerous vital signs. Participants are 45 or older and will be monitored for the firs…

This study follows 1,000 hospitalized adults with acute kidney injury to understand how kidneys recover and what long-term problems may arise, such as chronic kidney disease, heart issues, or dementia. Researchers will compare patients with kidney injury to those without to ident…