The Netherlands Cancer Institute

This study tests a drug called trastuzumab-deruxtecan (T-DXd) in people with HER2-positive breast cancer that has spread to 1-5 distant spots (oligo-metastatic). The goal is to shrink or eliminate all cancer with a year of treatment, including local therapies like surgery or radi…

This study tests whether giving a combination of chemotherapy (carboplatin/paclitaxel) and an immunotherapy drug (pembrolizumab) before surgery can completely eliminate cancer in men with advanced penile cancer that has spread to lymph nodes. About 27 participants will receive th…

This study is for women aged 51 or older whose breast cancer has returned in the same breast or who have a new breast cancer in that breast. The goal is to see if giving a focused, short course of radiation before surgery is safe and effective enough to allow breast-conserving tr…

This study tests whether giving two immunotherapy drugs (nivolumab and relatlimab) before surgery can help some patients with stage II-IIIa bladder cancer avoid bladder removal. About 90 participants will receive either one or both drugs, and doctors will check if the cancer disa…

This study tests whether a shorter, more intense radiation schedule (5 sessions instead of 20) with a higher dose to the main tumor can better control intermediate- or high-risk prostate cancer. About 484 men will be randomly assigned to one of the two treatments. The goal is to …

This study is for people with soft tissue sarcoma who need radiation before surgery. It compares a standard 14-session radiation schedule with a shorter 5-session schedule to see if the shorter course causes fewer wound complications after surgery while still controlling the tumo…

This study tests whether adding a targeted drug (olaparib) to heated chemotherapy given during surgery can safely treat advanced ovarian cancer. About 55 adults with stage III ovarian cancer will take olaparib pills before and after surgery. The goal is to find the best dose and …

This study compares bevacizumab, a drug that blocks blood vessel growth, to standard steroid treatment for people with brain damage from radiation therapy. About 408 adults with brain tumors or high-grade glioma who develop symptomatic radiation necrosis will be randomly assigned…

This study is testing whether giving a short course of immunotherapy drugs before surgery can help treat early-stage colon cancer. About 353 adults with stage 1-3 colon cancer will receive the treatment for 6-12 weeks before their tumor is removed. The goal is to see if this appr…

This study tests two immunotherapy drugs, botensilimab and balstilimab, given before surgery to people with certain solid tumors that can be removed. The goal is to see if the drugs can shrink or eliminate the tumor before surgery. About 133 adults with either mismatch repair def…

This study tests whether a special ultrasound with contrast dye can find the first lymph node where cancer might spread, instead of using the standard radioactive method. About 91 adults with melanoma, breast cancer, or head & neck cancer will take part. If it works, it could mak…

This study tests a new type of PET scan (Ga68-PSMA) to see if it can tell the difference between a growing tumor and radiation scar in people with brain metastases from lung cancer, melanoma, or breast cancer. About 100 adults who have had radiation treatment will get the scan. T…

This study tests whether injecting a gel called sodium thiosulfate into the middle ear before each cisplatin chemotherapy session can prevent hearing loss. About 100 adults with head and neck cancer will receive the gel in one ear only, and the treated ear will be compared to the…

This study tests whether giving a lower radiation dose to healthy parts of the prostate, while keeping a high dose only to visible tumors, can reduce bowel and urinary side effects in men with low- or intermediate-risk prostate cancer. About 54 men will receive two MRI-guided rad…

This study looks at whether the phase of a woman's menstrual cycle when she starts chemotherapy affects how well the treatment works. Researchers will collect blood samples from 100 premenopausal women with triple-negative breast cancer on the day they begin neoadjuvant chemother…

This study looks at the long-term challenges faced by people with advanced gastrointestinal stromal tumor (GIST) who have been taking targeted therapy (TKI) for at least 2 years. Researchers will track quality of life, treatment side effects, and financial burden for up to 10 yea…

This study follows 100 people with stage III triple-negative breast cancer who are receiving standard treatment. Researchers will collect information from medical records and ask participants to fill out quality-of-life questionnaires on a mobile app at nine different times. Some…