The Netherlands Cancer Institute

This phase III trial tests whether a personalized, high-dose chemotherapy followed by stem cell rescue can improve cure rates for people with high-risk, BRCA1-like breast cancer. The study includes 174 participants with stage III, HER2-negative tumors. The goal is to see if this …

This study tests whether adding heated chemotherapy directly into the abdomen during surgery helps people with stage III ovarian cancer live longer. About 538 participants will be randomly assigned to standard surgery alone or surgery plus the heated chemo. The main goal is to se…

This study tests whether giving a specific immunotherapy drug again, along with another drug and targeted radiation, can help control advanced non-small cell lung cancer. About 54 people whose cancer stopped responding to standard immunotherapy will receive this combination. The …

This study compares a shorter, 2-week radiation schedule to the standard 5-week schedule for people with soft tissue sarcomas (a type of cancer in muscles or fat). The goal is to see if the shorter course leads to similar wound healing after surgery and keeps the cancer from comi…

This study tests whether giving immunotherapy before surgery can shrink kidney tumors and reduce the chance of cancer coming back. About 69 adults with a high-risk type of kidney cancer will receive one of three drug combinations before their operation. The goal is to see which t…

This study tests whether a special scan (SPECT/CT) can map where a head and neck tumor drains lymph fluid. If the scan shows no drainage to the opposite side of the neck, doctors can safely avoid radiating that side, reducing side effects. About 90 patients with newly diagnosed h…

This study aimed to see if adding a new drug (LY3200882) to a standard chemotherapy (capecitabine) could help people with advanced colorectal cancer that no longer responded to treatment. It was designed for patients whose tumors had a specific genetic signature. However, the stu…

This study looks at whether women with a very early, low-risk form of breast cancer called DCIS can be safely monitored with regular check-ups instead of receiving immediate surgery or radiation. Many low-risk DCIS lesions may never cause health problems, so the goal is to avoid …

This study tests the drug pembrolizumab in 25 adults with a specific type of advanced colorectal cancer (dMMR) that cannot be surgically removed. The goal is to see if the drug can shrink tumors enough to allow surgery or avoid it altogether. Participants receive pembrolizumab an…

This study tests a new way to give radiation for prostate cancer that aims to reduce side effects. Twenty men with intermediate-risk prostate cancer will receive a lower dose of radiation to the whole prostate but a higher dose to the tumor itself, using a special MRI-guided mach…

This study tests whether a genetic marker (BRCA-like) can predict which chemotherapy combination works best for people with advanced triple-negative breast cancer. About 304 participants receive either carboplatin-cyclophosphamide or paclitaxel, with or without the immunotherapy …